Development of Complete Intraluminal Tapering Graft Made of Sintered Hyroxyapatite Tubings with Newly Invented Introducing Catheter

带有新发明导管的烧结羟基磷灰石管完整腔内锥形移植物的研制

• 批准号: 01480339
• 负责人: TSUJI Takayuki
• 金额: $ 2.56万
• 依托单位: Institute for Medical & Dental Engineering, Tokyo Medical & Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480339/
• 关键词: Aortic aneurysm; Apatite graft; complete intraluminal graft; Double-balloon catheter; Prevention of aneurysmal rupture; Less-invasive operation; Tapering graft; ダブルバル-ン・カテ-テル; 完全内挿型人工血管; ガ-ドスパイラルリング,; 細口径人工血管,; 完全内挿型人工血管,; 大動脈; ダブルバル-ンカテ-テル /

A simple operative method for aortic anerysm was developed in dog experiments. A tapered polymer graft which is supported externally with polypropylene spiral ring and has different calibered hydroxyapatite-coated titanium tubings at both the ends of the graft was developed with an invention of the special catheter for introduction of the graft into the aorta without giving injury to the inner aortic wall.The cather consisting of two coaxial catheters having balloons at the tip of the inner and outer catheters was inserted via aortotomy into the canine aorta occluded proximally with a clamping forcepts. The graft was smoothly introduced towards downstream guided with the outer catheter dilating the aortic wall with the inflated balloon while the backflow from the distal aorta was occluded with the inflated balloon of the inner catheter. The rigid tubings implanted in 10 dogs did not induce aortic rupture or pseudoaneurysm in long term observation up to 3 years.The aneurysm separated from the blood stream will be clotted and set free from rupture. This method shorting the operation time will improve the operative results for the highly aged patients with aneurysm.

在狗实验中开发了一种简单的主动脉厌食的手术方法。 A tapered polymer graft which is supported externally with polypropylene spiral ring and has different calibered hydroxyapatite-coated titanium tubings at both the ends of the graft was developed with an invention of the special catheter for introduction of the graft into the aorta without giving injury to the inner aortic wall.The cather consisting of two coaxial catheters having balloons at the tip of the inner and outer catheters was通过主动脉切开术插入犬主动脉，并用夹紧的知识闭塞。将移植物平滑地引入下游，外导管扩张了主动脉壁，并用膨胀的气球扩张，而远端主动脉的回流被内部导管的充气球囊闭塞。植入10只狗的刚性管不会在长期观察中诱导主动脉破裂或假性动脉瘤。长达3年。与血流分离的动脉瘤将被凝结并摆脱破裂。此方法缩短操作时间将改善高年老的动脉瘤患者的手术结果。

项目成果

T. Tsuji: "Research and development of medical materials and artificial organs" Journal of The Japan Pharmaceutical Association. 43(4). 1201-1205 (1991)

T. Tsuji：《医疗材料和人造器官的研究与开发》日本药学会会刊。

辻 隆之: "医用材料,講控収録集「医療を支える先端技術」" 1989年第3回「大学と科学」公開シンポジウム組織委員会, 361 (1989)

Takayuki Tsuji：“医学材料，‘支持医疗保健的先进技术’讲座集”，1989年第3届“大学与科学”公共研讨会组委会，361（1989）

T. Tsuji, K. Imanishi, K. Muneoka, H. Aoki, T. Togawa, Y. Shin, and K. Suma: "Hydroxyapatite Intraluminal graft with a newly developed introducing catheter" MRS Int'l Mtg Adv Mats. 1. 381-386 (1989)

T. Tsuji、K. Imanishi、K. Muneoka、H. Aoki、T. Tokawa、Y. Shin 和 K. Suma：“使用新开发的引入导管进行羟基磷灰石腔内移植” MRS Intl Mtg Adv Mats。

辻 隆之: "人工血管・気管・人工弁「21世紀へ羽ばたくセラミックス」" 日本セラミックス協会編 オ-ム社, 614 (1991)

辻隆之：《人造血管、气管和人造瓣膜：“飞向21世纪的陶瓷”，日本陶瓷协会编，Ohmsha，614（1991）

辻 隆之: "医用材料と人工臓器の開発と進展" 日本薬剤師雑誌. 43. 1201-1205 (1991)

Takayuki Tsuji：“医疗材料和人造器官的开发和进展”日本药剂师杂志 43. 1201-1205 (1991)。