Development of Multifunctional Liquid-Liquid Oxygenator

多功能液液充氧器的研制

• 批准号: 63870053
• 负责人: TSUJI Takayuki
• 金额: $ 5.7万
• 依托单位: Institute for Medical & Dental Engineering, Tokyo Medical & Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B).
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63870053/
• 关键词: ECMO; EVA hollow fiber; Hyperbaric liquid-liquid oxygenator; Multifunctional oxygenator; 差圧自動制御装置; EVA; 高圧気液両相型人工肺; ECMO; マスフロ-メ-タ; 高圧液相型人工肺; ガスフロ-メ-タ; 高圧液ー液型人工肺; 多機能型人工肺; キャピラリ人工肺; EVAホローファイバ; 抗血栓性材料

Hyperbaric liquid-liquid oxygenator made of ethylene vinyl alcohol copolymer (EVA) hollow fiber was developed in which gas exchange took place between venous blood and oxygen carrier solution such as saline, dialysate, or artificial blood (FC43). Oxygen carrier solution was saturated in the air-tight circuit with hyperbaric (up to 1.0 atm added) pure oxygen across the EVA membrane which is known to need small amount of heparin in use for hemodialysis. High pressure (Ps) was controlled with a pressure regulator, and oxygen flow rate, by a mass flowmeter. Solution at 37^ﾟC shifted at the rate of 0.94ml/min per at the transmembrane pressure of 10 mmHg in the oxygenator (0.8m^2) into the blood circuit. Shifted solution into the blood circuit was ultrafiltrated with a dialyzer interposed in the downstream circuit and recirculated to the pressurized circuit.This system working not only as an oxygenator but also as a hemodialyzer with small amount of heparin and without plasma leakage is suitable for ECMO for a neonate.

开发了由乙烯乙烯醇共聚物（EVA）中空纤维制成的高压液-液氧合器，其中静脉血与盐水、透析液或人工血液（FC43）等氧载体溶液在饱和氧载体溶液之间进行气体交换。气密回路，高压（最多添加 1.0 个大气压）纯氧穿过 EVA 膜，已知需要少量肝素血液透析用压力调节器控制高压（Ps），并通过质量流量计控制氧气流速，氧合器中的跨膜压力为 10 mmHg，溶液在 37°C 下以 0.94ml/min 的速率变化。 (0.8m^2) 进入血液回路中，用插入下游回路的透析器对转移到血液回路中的溶液进行超滤，并再循环至加压回路。该系统既可作为氧合器，又可作为血液透析器，含有少量肝素和血浆，无泄漏，适用于新生儿ECMO。

项目成果

Tsuji T, Tanishita K, Takahashi M, Togawa T: "Development of a multifunctional oxygenator made of EVA hollow fiber" Jpn. J. Artif. Organs. (1991)

Tsuji T、Tanishita K、Takahashi M、Tokawa T：“开发由 EVA 中空纤维制成的多功能充氧器” Jpn。

Tanishita K, Tsuji T, Sekido A, Tatsuo Togawa: "Gas transfer in the oxygenator made of hollow fiber with three layered composite membrane" Jpn. J. Artif. Organs. (1991)

Tanishita K、Tsuji T、Sekido A、Tatsuo Tokawa：“由三层复合膜中空纤维制成的充氧器中的气体传输”Jpn。

高橋誠: 医用電子と生体工学. 27. (1989)

高桥诚：医疗电子学和生物工程。27。（1989）

鈴木秀雄: 医用電子と生体工学. 26(特). 361 (1988)

铃木秀夫：医疗电子学和生物工程 26（特刊）361（1988）。

辻 隆之他: "エチレンビニ-ルアルコ-ル共重合体ホロ-ファイバ液相型人工肺による長期呼吸補助システムの開発に関する実験的研究" エル・エス・ティ学会誌. 3. 20-26 (1990)

Takayuki Tsuji 等：“使用乙烯乙烯醇共聚物全纤维液相氧合器开发长期呼吸支持系统的实验研究”LST 杂志 3. 20-26 (1990)。