Development of Multifunctional Liquid-Liquid Oxygenator

多功能液液充氧器的研制

• 批准号: 63870053
• 负责人: TSUJI Takayuki
• 金额: $ 5.7万
• 依托单位: Institute for Medical & Dental Engineering, Tokyo Medical & Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B).
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63870053/
• 关键词: ECMO; EVA hollow fiber; Hyperbaric liquid-liquid oxygenator; Multifunctional oxygenator; 差圧自動制御装置; EVA; 高圧気液両相型人工肺; ECMO; マスフロ-メ-タ; 高圧液相型人工肺; ガスフロ-メ-タ; 高圧液ー液型人工肺; 多機能型人工肺; キャピラリ人工肺; EVAホローファイバ; 抗血栓性材料

Hyperbaric liquid-liquid oxygenator made of ethylene vinyl alcohol copolymer (EVA) hollow fiber was developed in which gas exchange took place between venous blood and oxygen carrier solution such as saline, dialysate, or artificial blood (FC43). Oxygen carrier solution was saturated in the air-tight circuit with hyperbaric (up to 1.0 atm added) pure oxygen across the EVA membrane which is known to need small amount of heparin in use for hemodialysis. High pressure (Ps) was controlled with a pressure regulator, and oxygen flow rate, by a mass flowmeter. Solution at 37^ﾟC shifted at the rate of 0.94ml/min per at the transmembrane pressure of 10 mmHg in the oxygenator (0.8m^2) into the blood circuit. Shifted solution into the blood circuit was ultrafiltrated with a dialyzer interposed in the downstream circuit and recirculated to the pressurized circuit.This system working not only as an oxygenator but also as a hemodialyzer with small amount of heparin and without plasma leakage is suitable for ECMO for a neonate.

开发了由乙烯乙烯基醇共聚物（EVA）中空纤维制成的高压液液氧合，其中在静脉血液和氧气载体溶液（例如盐水，透析液或人造血液）之间进行气体交换（FC43）。氧气载体溶液在气密电路中饱和，跨EVA膜的高压（高达1.0 atm）纯氧气饱和，这是众所周知需要少量用于血液透析的肝素。高压（PS）由压力调节器和氧气流量通过质量流量计控制。 37^c的溶液以10 mmHg的跨膜压力（0.8m^2）的跨膜压力以0.94ml/min的速率移动到血回路。将溶液转移到血回路中，用透明体在下游电路中插入并再循环到加压电路中。该系统不仅作为氧化剂，而且还作为肝素少量且没有血浆泄漏的血液凝胶，适用于ECMO的Neononate。

项目成果

Tsuji T, Tanishita K, Takahashi M, Togawa T: "Development of a multifunctional oxygenator made of EVA hollow fiber" Jpn. J. Artif. Organs. (1991)

Tsuji T、Tanishita K、Takahashi M、Tokawa T：“开发由 EVA 中空纤维制成的多功能充氧器” Jpn。

Tanishita K, Tsuji T, Sekido A, Tatsuo Togawa: "Gas transfer in the oxygenator made of hollow fiber with three layered composite membrane" Jpn. J. Artif. Organs. (1991)

Tanishita K、Tsuji T、Sekido A、Tatsuo Tokawa：“由三层复合膜中空纤维制成的充氧器中的气体传输”Jpn。

高橋誠: 医用電子と生体工学. 27. (1989)

高桥诚：医疗电子学和生物工程。27。（1989）

鈴木秀雄: 医用電子と生体工学. 26(特). 361 (1988)

铃木秀夫：医疗电子学和生物工程 26（特刊）361（1988）。

辻 隆之他: "エチレンビニ-ルアルコ-ル共重合体ホロ-ファイバ液相型人工肺による長期呼吸補助システムの開発に関する実験的研究" エル・エス・ティ学会誌. 3. 20-26 (1990)

Takayuki Tsuji 等：“使用乙烯乙烯醇共聚物全纤维液相氧合器开发长期呼吸支持系统的实验研究”LST 杂志 3. 20-26 (1990)。