Anatomical and physiological characteristics of the peripheral vestibular endorgan, vestibular nucleus and vestibulo-cerebellum

外周前庭内器、前庭核和前庭小脑的解剖和生理特征

• 批准号: 03670815
• 负责人: HIMI Tetsuo
• 金额: $ 1.22万
• 依托单位: Sapporo Medical University, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670815/
• 关键词: Vestibular endorgan; Vestibular nucleus; Vertical eye movement; Brain stem; Substance P; NK1 receptor; RT-PCR; 眼球運動; 前庭小脳; 内耳; 前庭神経; 細胞接着因子; 発生学; 免疫組織

1. In vestibular system, little is known of the functional significance of Substance P (SP). In this study, the expression of mRNA encoding Neurokinin 1 receptor (NK1R) as a receptor of SP was examined in rat inner ear using RT-PCR method. NK1R mRNA was observed in both cochlear tissue and vestibular one.2. Spontaneous nystagmus was examined in patients with lateral medullary infarct syndrome. It is suspected that torsional eye movements in this syndrome may originate not in ventral but in rostral and dorsal lesions of the medulla, including the vestibular nucleus, which is related to torsional and vertical eye movements.3. The new etiology of the downbeat nystagmus was clarified. The presented case shows clear evidence of downbeat nystagmus arising from compression of vertebral arteries to the medulla oblongata. Surgical neurovascular decompression reveres the progression of symptoms.4. The phenomenon appeared to be part of the "vestibular agnosia" did not cause by a lesion of the vestibular nucleus and/or vestibular endorgans.

1。在前庭系统中，几乎没有知识的物质P（SP）的功能意义。在这项研究中，使用RT-PCR方法在大鼠内耳中检查了编码神经蛋白1受体（NK1R）作为SP受体的mRNA的表达。在人工耳蜗和前庭1中观察到NK1R mRNA。2。在侧髓梗塞综合征患者中检查了自发的眼球震颤。怀疑该综合征中的扭转眼运动可能不是腹侧的，而是在延髓和背侧病变中，包括前庭核，这与扭转和垂直眼运动有关。3。澄清了沮丧的眼球震颤的新病因。提出的案例显示出明确的证据表明，椎动脉压缩到髓质的延伸性。手术神经血管减压尊敬症状的进展。4。该现象似乎是“前庭狂热者”的一部分，这不是由前庭核和/或前庭内虫的病变引起的。

项目成果

Tetsuo Himi, Akikatsu Kataura: "Oblique periodic alternating nystagmus provoked by intermittent vertebral artery compression" Equilibrium Res. 52. 524-529 (1993)

Tetsuo Himi、Akikatsu Kataura：“间歇性椎动脉受压引起的斜周期性交替眼球震颤”平衡研究。

Tetsuo Himi, Hideaki Shirasaki, Iwao Yoshioka, Akikatsu Kataura: "Neurokinin 1 receptor mRNA detected by RT-PCR in rat inner ear" Hearing Res. (in submitted).

Tetsuo Himi、Hideaki Shirasaki、Iwao Yoshioka、Akikatsu Kataura：“通过 RT-PCR 检测大鼠内耳中的神经激肽 1 受体 mRNA”听力研究。

氷見徹夫: "神経血管圧迫症候群" 日耳鼻. 96. 720-723 (1993)

Tetsuo Himi：“神经血管压迫综合症”Nippon Otohana 96. 720-723 (1993)

氷見徹夫、形浦昭克: "ワレンベルグ症候群における延髄病変部位と自発眼振との関連" Equilibrium Res. 52. 175-180 (1993)

Tetsuo Himi，Akikatsu Kataura：“瓦伦堡综合征中髓质病变位置与自发性眼球震颤之间的关系”平衡研究 52. 175-180 (1993)

Tetsuo Himi: "Downbeat Nystagmus with compression of Medulla oblongata by the Dolichooctatic Vertebral Arteries" Am J Otol. 16(in press). (1995)

Tetsuo Himi：“多利丘克椎动脉压迫延髓而导致眼球震颤”Am J Otol。