NMR machine, 600 MHz

核磁共振机，600 MHz

• 批准号: 523962002
• 金额: --
• 依托单位: Humboldt-Universität zu Berlin
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/523962002?language=en
• 关键词: NMR; machine; 600; MHz

The department of chemistry of the Humboldt Universität zu Berlin requires a high-frequency 600 MHz NMR device to carry out its research. The new machine will be a replacement for a very well utilised device that was commissioned in 1993. The console was replaced in 2005 and repairs by the manufacturer can no longer be guaranteed. Due to the age of the magnet, a connection to the helium recovery system has not been possible so far, i.e. a new unit would also save running costs considerably. In addition, the magnet cannot be cooled below -10°C due to its fragility. The personnel as well as the experience and competence for high-field NMR spectroscopy are existing. The device is needed by a number of research groups whose research work requires NMR measurements with high resolution and sensitivity. The device will also be used by the specified research groups within the framework of research networks. In the field of bioorganic chemistry, protein domains and nucleic acid strands are investigated. Accordingly, the requirements for sensitivity and resolution of the measurements in this area are very high. Furthermore, many of the systems to be studied exhibit a dynamic behavior on the NMR time scale, the investigation of which also requires a high-frequency device. Among them are metal complexes as well as supramolecular compounds. A 3-channel device is crucial for the planned measurements. In the field of inorganic chemistry, correlation and decoupling experiments must be carried out due to the high bandwidth of nuclei to be measured, which often require three channels. Especially in the field of low-gamma nuclei (e.g. for 103Rh), sensitivity plays a crucial role, even when applying magnetisation transfer from more sensitive nuclei such as 1H, 19F or 31P. For the measurement of common triple resonance experiments of protein domains as well as nucleic acids, a 3-channel spectrometer is also mandatory.

洪堡大学化学系柏林曾要求使用高频600 MHz NMR设备进行研究。这台新机器将替代1993年委托使用的非常好的设备。该控制台在2005年被替换，制造商的维修不再可保证。由于磁铁的年龄，到目前为止，与氦恢复系统的连接是不可能的，即，一个新单元也可以大大节省运行成本。另外，由于其脆弱性，磁铁无法在-10°C以下冷却。人员以及高场NMR光谱的经验和能力存在。许多研究小组需要该设备，其研究工作需要具有高分辨率和敏感性的NMR测量。该设备还将在研究网络框架内的指定研究小组使用。在生物有机化学领域，研究了蛋白质结构域和核酸链。彼此之间，该领域测量值的敏感性和分辨率的要求很高。此外，在NMR时间尺度上，许多要验证的系统都可以使动态行为进行动态行为，其投资也需要高频设备。其中包括金属配合物以及超分子化合物。 3通道设备对于计划的测量至关重要。在无机化学领域，由于要测量的核带宽高，必须进行相关性和去耦实验，这通常需要三个通道。尤其是在低伽马核（例如103RH）领域，即使使用更敏感的核（例如1H，19F或31p），敏感性也起着至关重要的作用。为了测量蛋白质结构域和核酸的常见三重共振实验，也必须进行3通道光谱仪。