Improvement of electrodialytic processes performances for biofood applications using innovative electric current conditions

使用创新电流条件改善生物食品应用的电渗析工艺性能

• 批准号: RGPIN-2018-04128
• 负责人: Bazinet, Laurent
• 金额: $ 3.42万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=712752
• 关键词: Improvement; electrodialytic; processes; performances; biofood

Despite strong potential applications in the food, biopharmaceutical and biotechnology industries, a common problem with electrodialytic processes is membrane fouling. The most problematic ion-exchange membrane (IEM) fouling issues are scaling and fouling by peptides and proteins. Therefore, our research program seeks to understand how membrane characteristics and current mode conditions influence fouling and migration of food matrix components, as well as electroconvective vortex formation when biofood matrices undergo electrodialysis. The hypothesis of this research project is that the current mode (continuous current, reverse polarity (RP) and pulsed electric field (PEF)), current regime (underlimiting, limiting and overlimiting), current mode parameters (pulse/pause combinations, RP duration) and physicochemical characteristics of the membranes (nanopore size and distribution, hydrophilicity/hydrophobicity, ion-exchange capacity) affect the transport of food matrix components (mineral, peptides and proteins), their potential interactions with membranes and the resulting bioactivities of peptide fractions after application of electrodialytic processes. We defined three specific objectives for the proposed 5-year research program to answer this hypothesis according to the most problematic fouling type(s) related to each electrodialytic process: 1) To study the effects of the physicochemical characteristics of IEMs and PEF conditions on the formation of electroconvective vortices and IEM fouling mechanisms by food matrix components (mineral and peptides) during conventional electrodialysis (ED); 2) To study the impact of current modes and parameters on peptide fouling, migration selectivity, recovery yields and resulting bioactivities during electrodialysis with filtration membranes and 3) To understand the impact of PEF parameters on the prevention of mineral and protein fouling of membranes during electrodialysis with bipolar membranes. This research program will allow a better understanding of the relationships between food matrix components/nature of potential fouling, membrane characteristics/fouling prevention and current modes/fouling mitigation, as well as help to prevent membrane fouling in future and existing applications. It will also provide pertinent information about scaling up electrodialytic processes in terms of fouling prevention, and will highlight new areas of research and applications of the technology in the field of functional food and nutraceuticals. This research program will lead to a major breakthrough in scientific knowledge and research, not only for Canadian industries but also internationally and will be a unique opportunity to train needed highly qualified personnel.

尽管在食品、生物制药和生物技术行业具有强大的应用潜力，但电渗析过程的一个常见问题是膜污染。最成问题的离子交换膜 (IEM) 污染问题是肽和蛋白质的结垢和污染。因此，我们的研究计划旨在了解膜特性和电流模式条件如何影响食品基质成分的污垢和迁移，以及生物食品基质进行电渗析时电对流涡流的形成。该研究项目的假设是电流模式（连续电流、反极性（RP）和脉冲电场（PEF））、电流状态（下限、限制和超限）、电流模式参数（脉冲/暂停组合、RP持续时间） ）和膜的物理化学特性（纳米孔尺寸和分布、亲水性/疏水性、离子交换能力）影响食品基质成分（矿物质、肽和蛋白质）的运输，它们与应用电渗析过程后的膜和肽级分的生物活性。我们为拟议的 5 年研究计划定义了三个具体目标，以根据与每个电渗析过程相关的最有问题的污垢类型来回答这一假设： 1) 研究 IEM 和 PEF 条件的物理化学特性对传统电渗析 (ED) 过程中食品基质成分（矿物质和肽）形成电对流涡流和 IEM 结垢机制； 2) 研究当前模式和参数对过滤膜电渗析过程中肽污染、迁移选择性、回收率和生物活性的影响，以及 3) 了解 PEF 参数对防止电渗析过程中矿物质和蛋白质污染的影响与双极膜。 该研究计划将有助于更好地了解食品基质成分/潜在污染性质、膜特性/污染预防和当前模式/污染缓解之间的关系，并有助于防止未来和现有应用中的膜污染。它还将提供有关在防止结垢方面扩大电渗析过程的相关信息，并将重点介绍该技术在功能性食品和营养保健品领域的新研究和应用领域。该研究计划将带来科学知识和研究的重大突破，不仅对加拿大工业界而且对国际而言，并将是培训所需高素质人才的独特机会。