Reconsideration of pathogenesis and pathological classification of human caries pulpitis to apical periodontitis

人类龋齿牙髓炎至根尖周炎发病机制及病理分类的再思考

基本信息

批准号：
61570857
负责人：
NAGAI Noriyuki
金额：
$ 1.54万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

In this year, unmyelinated nerve fibers in human caries pulpitis were cheifly studied. Pathogenesis and pathological classification of human caries pulpitis were also reconsidered on the base of results of a last and this year.Materials and Methods:Samples were 15 caries teeth with acute severe symptoms. All teeth were upper or lower 3rd molars. After bisection of teeth crowns the pulpal tissue which underlying the caries lesion were, were immediately removed and fixed in 2% glutaraldehyde ・ 2% paraformaldehyde solution. Ultrastructural observation were same manner as a last year.Results:10/15 teeth were identified with the suppurative inflammation. In foci of inflammatory cell infiltration, mainly neutrophils, bundles of unmyelinated nerve fibers irregularly waved, and sometimes showed small spiral masses. On the other hand. 5/15 teeth were identified with fibrosis and tubercular proliferation of unmyelinated nerve fibers, so-called traumatic neuroma-like lesion without inflammatory c … More ell infiltration. Electron microscopically, unmyelinated nerves in the suppurative foci were almost surrounded by collagen fibrils, and no degenerative change of axons and schwann cells was found. In areas of loss of perinervous collagen fibrils, however, some vacuoles and/or dilation of axons was observed, nevertheless the basel lamina of schwann cells was intact. In so-called traumatic neuroma-like lesions, Schwann cells apparently showed reticular arrangements, and axons were involved in their arrangements.Summary:Our findings have allowed the hypothesis that inflammatory process of human caries pulpitis is modified by the chronic stimulation of the dental caries, and pathogenesis of human caries pulpitis differs essentially from the pulpitis caused by chemical of physical effects. Unmyelinated nerve of inflammatory foci may play a role in the intensive acute clinical symptoms of caries pulpitis. Finaly, pathological classification of human caries pulpitis may be summarized as follows: 1. early lesion, 2. suppurative lesion, 3. granulomatous lesion, 4. necrosis or gangrene of the dental pulp. Less

在今年，人类龋齿性牙髓炎中的不髓神经纤维被咀嚼。人类龋齿牙髓炎的发病机理和病理分类也被重新考虑在最后一年和今年的结果。所有牙齿均为上或下3磨牙。牙齿的一分为牙冠后，立即去除龋齿病变的牙髓组织，并将其固定在2％戊二醛・2％2％多聚甲醛溶液中。超微结构观察与去年相似。分子：补充炎症性的10/15牙齿。在炎症细胞浸润的焦点中，主要是中性粒细胞，不规则挥发的无髓神经纤维束，有时显示出较小的螺旋肿块。另一方面。鉴定出5/15齿的牙齿，纤维化和无髓神经纤维的结核病增殖，所谓的外伤性神经瘤样病变，而没有炎症C…更多的ELL浸润。通过电子显微镜，化脓灶中的无髓神经几乎是胶原蛋白原纤维周围的，并且没有发现轴突和雪旺氏细胞的退化变化。然而，在关节胶原蛋白原纤维失去的区域中，观察到轴突的一些液泡和/或词典，但是，schwann细胞的巴塞尔薄片是完整的。在所谓的外伤性神经瘤病变中，雪旺细胞显然表现出了网状排列，并且轴突参与其排列。避孕：我们的发现允许假设人类龋齿性肺炎的炎症过程通过人类龋齿的长期刺激人类龋齿和病原体造成的pulpiatiatiatiatiatiatiatiatiatiation pulpipitiation造成的牙骨病毒作用。炎症灶的无髓神经可能在肺炎的强化急性临床症状中起作用。最终的，人类的病理分类可以总结如下：1。早期病变，2。补充病变，3。肉芽肿性病变，4。牙髓的坏死或坏疽。较少的