Spectrometer console for a 500 MHz FT-NMR spectrometer

用于 500 MHz FT-NMR 光谱仪的光谱仪控制台

• 批准号: 510824417
• 金额: --
• 依托单位: Universität Bielefeld
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/510824417?language=en
• 关键词: Spectrometer; console; 500; MHz; FT

NMR spectroscopy has become a valuable and extremely useful analytical tool not only in the field of chemistry. To answer scientific questions about the structure and reactivity of molecules in solution, this method is absolutely essential. The instrument, which is the subject of the present application, is available to all work groups of the faculty. However, within the faculty it is mainly used by the synthetically oriented work groups of organic and inorganic chemistry. The scientific topics and issues addressed here are consequently multifaceted. They range from catalysis – enantioselective utilizing bio catalysts or metal-based catalytically active systems – to the analyses of peptide conformations and peptide-protein interactions, the structural elucidation of ethnomedical agents extracted from plant sources – obtained very often only on a submilligram scale – to the study of weak intra- and intermolecular donor-acceptor interactions in solution as well as complex formation of poly-Lewis acids. Almost all of these research topics require NMR measurements with suitable spectral resolution and sensitivity, which are sometimes very time consuming, to elucidate structures and reaction pathways. The oldinstrument was and still is an essential part of the NMR spectroscopic infrastructure of the faculty. It covers an essential part of the total measurement time and provides suitable spectral resolution and sensitivity due to its field strength. Renewal of the spectrometer electronicssystem is intended to ensure the operational capability for another 10 – 15 years, and also offer the possibility to implement current pulse sequences. The requested electronic-system is to guarantee that all users will have sufficient measurement time over the next 10 – 15 years to perform timely and efficient NMR measurements on their samples, which are produced in high numbers in the synthesis laboratories.

核磁共振波谱法不仅在化学领域已成为一种有价值且极其有用的分析工具，为了回答有关溶液中分子的结构和反应性的科学问题，该方法是绝对必要的，这也是本申请的主题。 ，适用于教师的所有工作组。然而，在教师内部，它主要由有机和无机化学的综合工作组使用，因此这里讨论的科学主题和问题是多方面的，从催化到对映选择性利用。生物催化剂或基于金属的催化活性系统 – 肽构象和肽-蛋白质相互作用的分析，从植物来源提取的民族药物的结构阐明 – 通常仅在亚毫克规模上获得 – 研究弱的分子内和分子间溶液中的供体-受体相互作用以及聚路易斯酸的复杂形成几乎所有这些研究主题都需要具有合适的光谱分辨率和灵敏度的核磁共振测量，这有时非常耗时。旧仪器过去和现在仍然是核磁共振光谱基础设施的重要组成部分，它涵盖了总测量时间的重要部分，并由于其场强的更新而提供了合适的光谱分辨率和灵敏度。光谱仪电子系统旨在确保另外 10 - 15 年的运行能力，并提供实现当前脉冲序列的可能性。所需的电子系统将保证所有用户在未来有足够的测量时间。需要 10 – 15 年的时间对合成实验室大量生产的样品进行及时有效的 NMR 测量。