Molecular mechanism for faithful chromosome segregation

染色体忠实分离的分子机制

• 批准号: 17013084
• 负责人: FUKAGAWA Tatsuo
• 金额: $ 32.32万
• 依托单位: National Institute of Genetics
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17013084/
• 关键词: 癌; ゲノム; 遺伝学; セントロメア; DT40細胞; 染色体分配; キネトコア; RNAiマシーナリー; CENPs; 染色体不安定性; 発がん機構

Faithful chromosome segregation during mitosis is essential for the accurate transmission of genetic material. To facilitate this, each replicated sister chromatid assembles a kinetochore on centromeric DNA which forms a dynamic interface with microtubules from the mitotic spindle. Dysfunction of the kinetochore leads cancer. However, molecular mechanism by which the kinetochore is formed, is still unclear. In this study, we have identified more than 20 molecules, which localize to the kinetochore and characterized each molecule.

有丝分裂过程中染色体的忠实分离对于遗传物质的准确传递至关重要。为了促进这一点，每个复制的姐妹染色单体在着丝粒 DNA 上组装一个动粒，与有丝分裂纺锤体的微管形成动态界面。动粒功能障碍会导致癌症。然而，动粒形成的分子机制仍不清楚。在这项研究中，我们鉴定了 20 多个分子，它们定位于动粒并表征了每个分子。

项目成果

実験医学(染色体分配に必要な動原体の分子構築)

实验医学（染色体分离所需的着丝粒的分子构建）

• 发表时间: 2009
• 作者: Fukagawa;T.;深川竜郎;岡田聖裕;堀哲也;Tatsuo Fukagawa;深川竜郎;深川竜郎;深川竜郎
• 通讯作者: 深川竜郎

The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.

• DOI: 10.1083/jcb.200509158
• 发表时间: 2006-04-10
• 期刊: The Journal of cell biology
• 作者: Kline SL;Cheeseman IM;Hori T;Fukagawa T;Desai A
• 通讯作者: Desai A

A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors

• DOI: 10.1128/mcb.01423-08
• 发表时间: 2009-04-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Kawashima, Toshiyuki;Bao, Ying Chun;Kitamura, Toshio
• 通讯作者: Kitamura, Toshio

Functional analysis of CENP-O class kinetochore proteins

CENP-O类动粒蛋白的功能分析

• 发表时间: 2008
• 作者: Koonin;E. V.;Wolf;Y. I.;Nagasaki;K.;Dolja;V. V;Tetsuya Hori
• 通讯作者: Tetsuya Hori

Role of Glucocorticoid Receptor in the Regulation of Cellular Sensitivity to Irinotecan Hydrochloride

• DOI: 10.1254/jphs.08219fp
• 发表时间: 2009-02-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Akagi, Takanori;Fukagawa, Tatsuo;Ohdo, Shigehiro
• 通讯作者: Ohdo, Shigehiro