Genetic alteration and cellular mucin phenotype of ulcerative colitis-associated colorectal carcinoma

溃疡性结肠炎相关结直肠癌的遗传改变和细胞粘蛋白表型

• 批准号: 16590270
• 负责人: AJIOKA Yoichi
• 金额: $ 2.05万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590270/
• 关键词: ulcerative colitis; colorectal carcinoma; cancerization; dysplasia; mucin phenotype; p53; MSI; K-ras; 潰瘍性大腸炎の癌化

1. p53 alteration was found in 3/4 colitic cancer and 4/4 dysplasia.2. 5/8 colitic cancers and 4/6 dysplasia demonstrated MUC2+/MUC5AC+ mucin phenotype3. Background colonic mucosa of colitic cancer revealed diffuse expression of MUC5AC4. In 5 cases of colitc cancer, no MSI status was found in cancer nor in their background mucosaCarcinogenesis in ulcerative colitis was thought as ; chronic persistent inflammation→cellular mucin phenotype conversion of the stem cell in the crypt→development of dysplasia→progression to carcinoma.To elucidate further mechanism underlying the cancerization in ulcerative colitis, it is required to analyze the genetic changes responsible for cellular phenotype conversion of the stem cell.

1. 在 3/4 结肠癌和 4/4 不典型增生中发现 p53 改变。2. 5/8 结肠癌和 4/6 不典型增生表现出 MUC2+/MUC5AC+ 粘蛋白表型3。 5例结肠癌，在癌症及其背景粘膜中均未发现MSI状态溃疡性结肠炎的致癌作用被认为是；慢性持续性炎症→隐窝干细胞的细胞粘蛋白表型转变→发育不良→进展为癌。为了进一步阐明溃疡性结肠炎癌变的机制，需要分析导致细胞癌变的遗传变化。干细胞的表型转变。

项目成果

Incidence and distribution of hybrid goblet cells in complete type intestinal metaplasia of the stomach

胃完全型肠化生中混合杯状细胞的发生率和分布

• 发表时间: 2005
• 期刊: Pathology Res and Prac 201
• 作者: Aihara R;Ajioka Y
• 通讯作者: Ajioka Y

病理学的診断(2)Dysplasia、癌の生検診断のプロセス

病理诊断（二）不典型增生，癌活检诊断的过程

• 发表时间: 2005
• 期刊: 早期大腸癌 9
• 作者: Tomida;S.;et al.;味岡 洋一
• 通讯作者: 味岡 洋一

Incidence and distribution of hybrid goblet cell in complete type intestinal metaplasia of the stomach

胃完全型肠化生中混合杯状细胞的发生率和分布

• 发表时间: 2005
• 期刊: Pathology Res and Prac 201
• 作者: Aihara R.;Ajioka Y.
• 通讯作者: Ajioka Y.

Colitic cancer

结肠癌

• 发表时间: 2005
• 作者: 渡辺聡明;味岡洋一 編
• 通讯作者: 味岡洋一 編

Re-evaluation of mucin phenotypes of gastric minute well-differentiated-type adenocarcinoma

胃微小高分化型腺癌粘蛋白表型的重新评估

• 发表时间: 2004
• 期刊: Pathology Int 54
• 作者: Shiroshita H;Ajioka Y
• 通讯作者: Ajioka Y