Studies on Selective Imaging of Coronary Territories Using Intravenous Myocardial Contrast Echocardiography

静脉心肌造影超声心动图对冠状动脉区域的选择性成像研究

基本信息

批准号：
14570667
负责人：
OHMORI Koji
金额：
$ 2.18万
依托单位：
Kagawa University, Faculty of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

We clarified the relationship between the fragility of microbubble shell and the range of blood flow velocity in destroying the microbubbles regarding the completeness of destruction in a flow model study. In patients study, we propose to evaluate the left (LCA) and right coronary (RCA) territories separately in a session, because the entire myocardial segments are rarely opacified at one time. Microbubble destruction and replenishment principle was useful to determine the severity of coronary stenosis. In dog experiments, we visualized the left main coronary trunk (LMT) on a short axis image of aortic root while the short axis view or the long axis view of the left ventricle was visualized with another transducer. Insonation of LMT with continuous wave Doppler mode for the microbubble destruction and low power pulse inversion harmonic mode (real-time imaging) for perfusion imaging during infusion of BR1 was suitable to obtain appreciable images while microbubble destruction significantly affected the signal intensity in LCA territory. However, problems remained unsolved ; the only microbubble clinically available Levovist is too fragile and is not suitable for real-time imaging, and technical issue to handle two transducers simultaneously in a limited echo window.We further studied the safeness of microbubble destruction. We found that destruction of microbubbles in a microcirculation causes capillary rupture resulting in microhemorrhage leading to local infiltration of leukocytes. Then, we further studied this phenomena and found that microbubbles attach to the activated leukocytes and are phagocytosed, which provided the basis for ultrasonic imaging of inflammation. In addition, we found that thus recruited leukocytes (macrophages) produce vascular endothelial growth factor, thereby enhance angiogenesis.

我们阐明了微泡壳的脆弱性与在流动模型研究中破坏破坏的完整性的微泡中的血流速度范围之间的关系。在患者研究中，我们建议在一次会议中分别评估左（LCA）和右冠状动脉（RCA）领土，因为整个心肌段很少一次不渗透。微泡破坏和补充原理对于确定冠状动脉狭窄的严重程度很有用。在狗实验中，我们在主动脉根的短轴图像上可视化左主冠状动力躯干（LMT），而短轴视图或左心室的长轴视图与另一个换能器可视化。通过连续波多普勒模式对LMT进行微气泡破坏和低功率脉冲反转和谐波模式（实时成像）进行灌注，用于在BR1输注过程中进行灌注成像，适合获得可观的图像，而微气泡破坏会显着影响LCA领域的信号强度。但是，问题尚未解决；唯一的微泡临床可用的Levovist太脆弱了，不适合实时成像，并且技术问题在有限的回声窗口中同时处理两个换能器。我们进一步研究了微泡破坏的安全性。我们发现，微循环中微泡的破坏会导致毛细管破裂，导致微毛发导致白细胞的局部浸润。然后，我们进一步研究了这种现象，发现微泡附着于活化的白细胞上并被吞噬，这为超声炎症的超声成像提供了基础。此外，我们发现因此募集的白细胞（巨噬细胞）产生血管内皮生长因子，从而增强血管生成。

项目成果

期刊论文数量（44）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model

DOI：
10.1161/01.cir.0000115586.25803.d5
发表时间：
2004-03-02
期刊：
CIRCULATION
影响因子：
37.8
作者：
Kondo, I;Ohmori, K;Kohno, M
通讯作者：
Kohno, M

Effect of microbubble fragility on transit rate measurement by contrast echography

微泡脆性对超声造影通过率测量的影响

DOI：
发表时间：
2003
期刊：
Ultrasound Med Biol 29・2
影响因子：
0
作者：
Ohmori K
通讯作者：
Ohmori K

Interaction with leukocytes : phospholipid-stabilized versus albumin-shell microbubbles

与白细胞的相互作用：磷脂稳定的微泡与白蛋白壳微泡

DOI：
发表时间：
2004
期刊：
Radiology 230・3
影响因子：
0
作者：
Takeuchi H
通讯作者：
Takeuchi H

A comparison of video and digital data in the assessment of myocardial perfusion abnormalities by myocardial contrast echocardiography.

通过心肌造影超声心动图评估心肌灌注异常的视频和数字数据的比较。

DOI：
发表时间：
2004
期刊：
Int J Cardiovasc Imaging 20(3)
影响因子：
0
作者：
Masugata H;Yukiiri K;Takagi Y;Ohmori K;Mizushige K;Kohno M
通讯作者：
Kohno M

Difference of optimal dose of contrast agent between gray-scale and power Doppler imaging in assessing graded coronary stenosis by myocardial contrast echocardiography.

心肌造影超声心动图评估分级冠状动脉狭窄时灰度多普勒成像和能量多普勒成像之间造影剂最佳剂量的差异。

DOI：
发表时间：
2003
期刊：
Invest Radiol 38(9)
影响因子：
0
作者：
Masugata H;DeMaria AN;Peters B;Lafitte S;Strachan GM;Kwan OL;Ohmori K;Mizushige K;Kohno M
通讯作者：
Kohno M