Development of Parametric Imaging of Myocardial Perfusion Using Ultrasonic Microbubble Destruction

超声微泡破坏心肌灌注参数化成像的发展

基本信息

批准号：
12670675
负责人：
OHMORI Koji
金额：
$ 2.05万
依托单位：
Kagawa Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

We devised a new intermittent imaging employing an ultrasound pulsing sequence that utilized ultrasonic microbubble destruction to quantitate myocardial blood flow (MBF).We devised a new intermittent imaging employing an ultrasound pulsing sequence that utilized ultrasonic microbubble destruction to quantitate myocardial blood flow (MBF). We found that abrupt shortening of ultrasound pulsing interval (PI) in myocardial contrast echocardiography during intravenous microbubble infusion produces a decay of contrast intensity (CI) along frame number (f), which fit tell to a decay function SI=α×exp(-β×f)+γ. Our study in vitro using a flow model revealed that α and β thus obtained reflect flow transit velocity. Subsequently, we performed an in vivo study in which MBF in rats was successfully quantitated with the new parameters derived from this formula. By defining myocardial velocityas Vel=1/(β/HR), where HR is heart rate, and myocardial blood volume as Vol=α+γ, MBF is determined as VelxVol … More = [1/(β/HR)](α+γ). MBF thus determined exhibited a close correlation with microsphere-derived MBF at baseline, during pharmacological hyperemia, and during coronary stenoses.Finally, we validated this method in clinical settings. The parameters obtained with harmonic power Doppler and commercially available microbubbles for clinical use, we examined the usefulness of the pulsing sequence. The extent of CI decay produced by PI shortening from 1:10 to 1:1 end-systolic ECG trigger during intravenous microbubble infusion exhibited a similar decay. The extent of CI decay:α/(α+γ) was found useful in quantification of coronary vasodilator reserve, which allowed defection of significant coronary stenoses with a sensitivity of 93 % and a specificity of 85%. In addition, multi-frame trigger that emitted a burst of 4 rapid pulses was found useful in standardizing microbubble concentration in the myocardium. The time duration from the beginning of segmental myocardial opacification after bolus microbubble injection to the burst in which the last pulse resulted in no opacification was correlated with myocardial blood volume, and thus the myocardial viability evaluated by 201-thallium uptake in infarcted segments inpatients. Less

我们设计了一种新的间歇性成像，该成像采用超声脉冲序列，利用超声波脉冲技术来定量心肌血流（MBF）。我们设计了一种新的间歇性成像，采用超声脉冲序列，使用超声波脉冲技术来定量心肌流动（MBF）。（PI）在静脉微气泡输注过程中心肌造影超声心动图中，沿框架数（F）产生造影剂强度（CI）的衰减，这表明衰减函数SI =α×EXP（-β×F）+γ。我们在体外使用流量模型的研究表明，因此获得的α和β反映了流动速度。随后，我们进行了一项体内研究，其中通过该公式得出的新参数成功地定量了大鼠中的MBF。通过定义心肌速度= 1/（β/hr），其中HR为心率，心肌体积为Vol =α+γ，MBF被确定为velxvol…More = [1/（β/HR）]（α+γ）。因此，MBF确定在基线，药物充血期间和冠状动脉促炎期间与微球来源的MBF密切相关。在本文中，我们在临床环境中验证了这种方法。用谐波功率多普勒和市售的微泡获取的参数用于临床使用，我们检查了PI缩短到1：10到1：1末端的末期体接ECG触发的CI衰变程度，在静脉内微泡输液中表现出类似的衰变。发现CI衰变的程度：α/（α+γ）在冠状动脉血管舒张剂储备中有用，该储备允许定义明显的冠状动脉狭窄，灵敏度为93％，特异性为85％。此外，发现发出4种快速脉冲爆发的多帧触发因在心肌中标准化微气泡浓度时有用。从节段性的心肌无糊精开始后，大推注微泡注射到爆发的时间持续时间，最后脉冲导致没有不糊精的爆发与心肌血容量相关，因此在不受欢迎的部门的进食部门的201- thallium摄取中，心肌的生存能力与心肌生存能力相关。