Mechanism of the prevention of the arteriosclerosis by exercise : Focused on the oxidative stress protective mechanism

运动预防动脉硬化的机制：关注氧化应激保护机制

基本信息

批准号：
15500500
负责人：
IKEDA Masaharu
金额：
$ 2.37万
依托单位：
University of Occupational Health and Environmental Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

The aim of this study was to investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.In this study, we investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.Results were as follows ;1.As a result of lifestyle modification, it was shown that the oxidative stress to the body was significantly influenced by an oxidative stress defense system, age, blood pressure, and BMI, and aerobic exercise reduced the oxidative stress.2.The state of the oxidative stress before intervention, and urine nitric oxide level and maximum oxygen uptake were involved in the difference in the blood lowering effect by lifestyle modification, and blood pressure reduction by lifestyle modification resulted in improving other cardiovascular risks.3.Blood pressure, BMI, lipid metabolism, insulin resistance, and lipid peroxidation were shown to improve after lifestyle modification. Nitric oxide(NO) biological availability was considered to contribute, in part, to hypotensive effects by lifestyle modification including exercise..4.Summation of cardiovascular risk factors (multiple risk factor) showed the effect on the increase in the severity of each risk factor and the synergistic effect on the increase in an cardiovascular risk. Severity of each risk factor was improved and the number of risk factors were reduced by participation in lifestyle modification program.5.Acute and chronic exercise prevented oxidative DNA damage by stimulating the nucleotide sanitizing mechanism and it was suggested that continuous aerobic exercise is effective for prevention of oxidative DNA damage.

本研究旨在从氧应激及其保护机制的角度探讨有氧运动预防动脉硬化的作用机制。结果如下： 1.由于生活方式的改变，机体的氧化应激受到氧化应激防御系统、年龄、血压、 2、干预前氧化应激状态、尿一氧化氮水平、最大摄氧量参与生活方式改变降血压效果、生活方式改变降血压效果的差异。生活方式的改变导致其他心血管风险的改善。3.生活方式改变后，血压、BMI、脂质代谢、胰岛素抵抗和脂质过氧化均得到改善。一氧化氮 (NO) 的生物利用度被认为在一定程度上有助于通过包括锻炼在内的生活方式改变来产生降血压作用。4.心血管危险因素（多种危险因素）的汇总显示了对每种危险因素严重程度增加的影响以及对心血管风险增加的协同作用。通过参与生活方式改变计划，各危险因素的严重程度得到改善，危险因素的数量减少。5.急性和慢性运动通过刺激核苷酸净化机制来预防氧化性DNA损伤，表明持续的有氧运动可以有效预防DNA 氧化损伤。