Mechanism of the prevention of the arteriosclerosis by exercise : Focused on the oxidative stress protective mechanism

运动预防动脉硬化的机制：关注氧化应激保护机制

基本信息

批准号：
15500500
负责人：
IKEDA Masaharu
金额：
$ 2.37万
依托单位：
University of Occupational Health and Environmental Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

The aim of this study was to investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.In this study, we investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.Results were as follows ;1.As a result of lifestyle modification, it was shown that the oxidative stress to the body was significantly influenced by an oxidative stress defense system, age, blood pressure, and BMI, and aerobic exercise reduced the oxidative stress.2.The state of the oxidative stress before intervention, and urine nitric oxide level and maximum oxygen uptake were involved in the difference in the blood lowering effect by lifestyle modification, and blood pressure reduction by lifestyle modification resulted in improving other cardiovascular risks.3.Blood pressure, BMI, lipid metabolism, insulin resistance, and lipid peroxidation were shown to improve after lifestyle modification. Nitric oxide(NO) biological availability was considered to contribute, in part, to hypotensive effects by lifestyle modification including exercise..4.Summation of cardiovascular risk factors (multiple risk factor) showed the effect on the increase in the severity of each risk factor and the synergistic effect on the increase in an cardiovascular risk. Severity of each risk factor was improved and the number of risk factors were reduced by participation in lifestyle modification program.5.Acute and chronic exercise prevented oxidative DNA damage by stimulating the nucleotide sanitizing mechanism and it was suggested that continuous aerobic exercise is effective for prevention of oxidative DNA damage.

这项研究的目的是研究有氧运动对动脉粥样硬化预防的影响的机制，从氧气应激的角度及其保护机制。在这项研究中，我们研究了有氧运动对动脉粥样硬化对预防动脉粥样硬化的影响的机制，从氧气应激及其保护性的氧气中的观点均表现出了改进的作用。身体受到氧化应激防御系统的显着影响，年龄，血压和BMI以及有氧运动减少了氧化应激。2。干预前的氧化应激状态，以及尿液一氧化物氧化物水平和最大的氧气水平和最大的氧气摄取涉及降低血液的降低效果，以及通过生活方式改性的降低效果，以及降低生活方式的降低。 BMI，脂质代谢，胰岛素抵抗和脂质过氧化作用显示在生活方式改变后可以改善。一氧化氮（NO）的生物学可用性被认为是通过生活方式修改（包括运动）的降压作用的部分作用。4。心血管危险因素（多重危险因素）对每种风险因素的严重程度的增加以及对心血管风险增加的协同作用的影响表明。通过参与生活方式修改程序来提高每个危险因素的严重程度，并减少了风险因素的数量。5。急性和慢性运动通过刺激核苷酸消毒机制来防止氧化性DNA损伤，并且建议连续有氧运动有效地预防氧化DNA损害。