Microbubble evaluation by ultrasonic wave micro holography method and fabrication of functionality bubble

超声波微全息法微泡评价及功能性气泡的制作

• 批准号: 15360215
• 负责人: YAMAKOSHI Yoshiki
• 金额: $ 9.79万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15360215/
• 关键词: Self organization; Microbubble; Ultrasonic wave; Manipulation; Micro object; Bjerknes force; Radiation force; Drug delivery system; 微小気泡; 気泡コンプレックス; ホログラフィ; マイクロ ホログラフィ; ドラツグ デリバリ システム

The purpose of this research is development of a new bubble operation technology that uses the supersonic wave. In this research, for this, two techniques were developed. The first method is a method of evaluating the bubble of calling "Supersonic wave microholography method". In site characteristic of micro bubbles inside the ultrasonic wave can be evaluated by using this method. The second method is a new control method by the ultrasonic wave of the bubble movement. This method is based on self organization of micro bubbles under the ultrasonic wave. By this method, bi-layered bubble mass (Inner layer is seed bubbles and outer layer is target objects), which is considered as important dynamics in future drug/gene delivery system, is easily fabricated. The self organization of this bubble and the application of the micro object were examined in respect of the theory, the numerical analysis, and the experiments. It was shown that the developed trapping technology of micro object based on self organization of the bubble was useful method in order to trap the micro objects. It can make a special mention of having done three invitation lectures relate with this subject in 2004.

这项研究的目的是开发一种利用超声波的新型气泡操作技术。在本研究中，为此开发了两种技术。第一种方法是被称为“超声波微全息法”的气泡评价方法。利用该方法可以评价超声波内部微气泡的现场特性。第二种方法是利用超声波控制气泡运动的新方法。该方法基于超声波下微气泡的自组织。通过这种方法，很容易制造双层气泡团（内层是种子气泡，外层是目标物体），这被认为是未来药物/基因递送系统的重要动力学。从理论、数值分析和实验方面探讨了该气泡的自组织及其在微观物体中的应用。结果表明，所开发的基于气泡​​自组织的微小物体捕获技术是捕获微小物体的有效方法。特别值得一提的是，2004年曾做过三场与该主题相关的邀请讲座。

项目成果

N.Masuda, T.Tsujita, T.Ebuchi, Y.Yamakoshi: "Low-Frequency Elastic Wave Imaging by Adaptive Combination of Fundamental and Tissue Harmonic Ultrasonic Waves"Jpn.J.Appl.Phys.. 42. 3271-3275 (2003)

N.Masuda、T.Tsujita、T.Ebuchi、Y.Yamakoshi：“基于基波和组织谐波超声波的自适应组合的低频弹性波成像”Jpn.J.Appl.Phys.. 42. 3271-3275 (2003)

Low-Frequency Elastic Wave Imaging by Adaptive Combination of Fundamental and Tissue Harmonic Ultrasonic Waves

基波和组织谐波超声波自适应组合的低频弹性波成像

• 发表时间: 2003
• 期刊: Jpn.J.Appl.Phys. 42
• 作者: N.Masuda;T.Tsujita;T.Ebuchi;Y.Yamakoshi
• 通讯作者: Y.Yamakoshi

Y.Yamakoshi: "Micro Bubble Aggregation by Interference of Incident and the Secondary Ultrasonic Waves and its Application to Buble Characterization"IEEE, International Symposium on Ultrasonics. 2003. 256-257 (2003)

Y.Yamakoshi：“通过入射和二次超声波的干扰进行微气泡聚集及其在气泡表征中的应用”IEEE，国际超声波研讨会。

新たな超音波医用技術の開拓

开发新的超声医疗技术

• 期刊: 検査技術 (印刷中)
• 作者: Kawano;T.;Kato;Y.;Tani;R.;Takao;H.;Sawada;K.;Ishida M.;山越芳樹
• 通讯作者: 山越芳樹

山越芳樹: "超音波の物理的性質と医用応用"総合臨床. 第53巻1号. 17-22 (2004)

Yoshiki Yamakoshi：“超声的物理特性和医学应用”，第 53 卷，第 1. 17-22 期（2004 年）。