Ultrasonic wave assisted micro bubble manipulation and it application

超声波辅助微气泡操控及其应用

• 批准号: 13650454
• 负责人: YAMAKOSHI Yoshiki
• 金额: $ 2.3万
• 依托单位: Faculty of Engineering, Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650454/
• 关键词: Ultrasonic waves; Micro bubbles; Radiation force; Bjerknes force; Trapping; Bubble manipulation; Ultrasonic contrast agent; 集合気泡; マニュピュレーション; 気泡集合; 操作

Micro air bubbles with a diameter of several micrometers or less attract attention in the field of a medical diagnosis and medical treatment. The research representative of this research is reporting the result in which it might inquire over the past several years about manipulation of the particle by the ultrasonic wave. In this research, the following results were obtained based on these results. 1) The evaluation of cellular dynamics which made full use of a simulation. 2) Detailed experimental examination containing from a basic experiment to an animal experiment. 3) Development of the new application based on these knowledge. The concrete results are follows. 1) About numerical analysis, the code in the 3-dimensional completeness model in consideration of the influence of the surface tension of a cellular film is completed. 2) It analyzed about nonlinear vibration of the air bubbles in the case where two or more air bubbles exist. The experimental system which can transmit four independent ultrasonic waves simultaneously based on a laboratory existing ultrasonic transmitting system was made. Examination about the influence erythrocyte affects cellular trapping, research of detailed cellular dynamics using the air bubbles were done.

直径为几微米或更少的微气泡在医疗诊断和医疗领域引起了人们的注意。这项研究的研究代表报告了过去几年通过超声波操纵粒子的结果。在这项研究中，根据这些结果获得了以下结果。 1）评估细胞动力学，该动力学充分利用了模拟。 2）详细的实验检查，其中包含从基本实验到动物实验的实验。 3）根据这些知识开发新应用程序。以下是具体的结果。 1）关于数值分析，考虑到细胞膜表面张力的影响，三维完整性模型中的代码已完成。 2）在存在两个或更多气泡的情况下，它分析了气泡的非线性振动。可以根据实验室现有的超声传输系统同时传输四个独立的超声波的实验系统。关于红细胞影响的影响会影响细胞捕获，使用气泡对详细的细胞动力学进行了研究。

项目成果

Masato Ida, Yoshiki Yamakoshi: "An Eulerian Scheme for Direct Numerical Simulation of Multibubble Dynamics in an Acoustic Field"Jpn.J.Appl.Phys.. Vol.40, No.5B. 3846-3851 (2001)

Masato Ida、Yoshiki Yamakoshi：“声场中多气泡动力学直接数值模拟的欧拉方案”Jpn.J.Appl.Phys.. Vol.40，No.5B。

Y.Yamakoshi, M.Koshiba, Y.Ozawa, N.Masuda: "Trapping of micro bubbles by ultrasnic waves"Jpn.J.Appl.Phys.. Vol.40. 1526-1527 (2001)

Y.Yamakoshi、M.Koshiba、Y.Ozawa、N.Masuda：“超声波捕获微气泡”Jpn.J.Appl.Phys.. Vol.40。

山越芳樹: "超音波による微小気泡のハンドリング"日本音響学会誌. Vol.58,No.10. 659-662 (2002)

Yoshiki Yamakoshi：“使用超声波处理微泡”，日本声学学会杂志，第 58 卷，第 659-662 期（2002 年）。

山越芳樹: "超音波による微小気泡のハンドリング"日本音響学会誌. Vol.58 No.10. 659-662 (2002)

Yoshiki Yamakoshi：“使用超声波处理微泡”日本声学学会杂志第 58 卷第 659-662 期（2002 年）。

Y.Yamakoshi, Y.Ozawa, M.Ida, N.Nasuda: "Effects of Bjerknes Forces on Gas-Filled Microbubble trapping by ultrasonic waves"Jpn.J.Appl.Phys.. Vol.40, No.5B. 3852-3855 (2001)

Y.Yamakoshi、Y.Ozawa、M.Ida、N.Nasuda：“Bjerknes 力对超声波捕获气体填充微泡的影响”Jpn.J.Appl.Phys.. Vol.40，No.5B。