Control of self-organization of microbubbles by ultrasonicwave and progressing to the medical treatment and biotechnology

超声波控制微泡自组织及其向医疗和生物技术的进展

基本信息

批准号：
17360188
负责人：
YAMAKOSHI Yoshiki
金额：
$ 9.86万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17360188/
关键词：
Micro bubble Ultrasonic wave Acoustic radiation force Drug Delivery System Bjerknes force Manipulation Self organization Bubble aggregation 気泡非線形振動酵母菌

项目摘要

The drug and the gene delivery system that effectively introduces the carrying drug solution and the gene in the cell are one of promising technologies in the future medical treatment. However, in order to achieve this technology, three basic technological developments are required. They are, dose improvement technology, which is used for introducing the drug or gene in the cell, targeted trapping technology of drug or gene vehicles, and controlled release technology of drug or gene inside the vehicles. In this research, "Group" control technology of bubbles was developed in order to develop sophisticated methods used in the future drug delivery system. The result of this research is achieved as follows.1.It proposed a new numerical simulation method that was able to analyze the movement of the bubble group. In this model, the set of the radiation pressure to the oscillating bubble caused by the secondary ultrasonic wave from the neighboring bubbles, the viscosity of a surrounding liquid are considered.2.The trapping technology of the yeast cells, which is based on micro bubble, was proposed.3.A novel technology of bubble manipulation using the self-organization of the bubble group was developed.It is considered that the new findings and novel technologies obtained in this research become basic technologies in developing the future drug or gene delivery system.

将携带药物溶液和基因有效引入细胞内的药物和基因递送系统是未来医疗中最有前途的技术之一。然而，为了实现这项技术，需要三项基本技术的发展。它们是，用于将药物或基因引入细胞内的剂量改进技术、药物或基因载体的靶向捕获技术以及药物或基因在载体内的控释技术。在这项研究中，开发了气泡的“群体”控制技术，以开发用于未来药物输送系统的复杂方法。本研究取得的成果如下：1.提出了一种新的能够分析气泡群运动的数值模拟方法。该模型考虑了相邻气泡的二次超声波对振荡气泡的辐射压力、周围液体的粘度等因素。 2、基于微气泡的酵母细胞捕获技术3.开发了一种利用气泡群自组织的气泡操纵新技术。认为本研究获得的新发现和新技术将成为开发未来药物或基因递送系统的基础技术。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Yeast cell trlping in ultrasonic wave field using ultrasonic contrast agent

使用超声波造影剂在超声波场中捕获酵母细胞

DOI：
发表时间：
2006
期刊：
Jpn. J. Appl. Phys. Vol.45, No.5B
影响因子：
0
作者：
山越芳樹;Y.Yamakoshi;山越芳樹;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi;Y.Yamakoshi
通讯作者：
Y.Yamakoshi

Ultrasonic wave assisted manipulation of micro bubbles and drug delivery system

超声波辅助微泡操控及药物输送系统