Internal micro pump system by ultrasonic wave

内部超声波微型泵系统

• 批准号: 07650470
• 负责人: YAMAKOSHI Yoshiki
• 金额: $ 1.47万
• 依托单位: GUNMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07650470/
• 关键词: Ultrasonic wave; Micro pump; Radiation force; Micro particle; Standing wave; 音響放射圧; 微小粒子; マイクロ ポンプ

It is clinically important to give medical treatment for circulatory diseases such as arterial sclerosis and thrombosis.For this purpose, micro mechanisms which are based on micro actuator controlled by micro CPU have been proposed. However, it may be difficult to apply these mechanisms in living tissues, because there are many problems to be solved in these mechanisms. For example, safety to the living tissues and reliability are not clear. In our research which is supported by the grant-in-aid, micro mechanisms which are based on the use of ultrasonic waves and micro particles are proposed and are studied. For example, when the micro particles are suspended in the ultrasonic standing waves and the standing waves shift laterally by shanging the phase of an ultrasonic wave, the micro particles move in the same lateral direction. This may become a micro scraper in the living tissues. The drag delivery system may be also designed in the same manner if the micro particles are trapped by the ultrasonic standing wave. In order to design such micro mechanisms including micro pump, micro scraper and micro particle trapping system, the basic experiments are carried out by using mimic vessels and characteristics of theses methods are presented.

为循环系统疾病（例如动脉硬化和血栓形成）提供医疗在临床上很重要。为此，已经提出了基于由微CPU控制的微执行器的微型机制。但是，可能很难在活组织中应用这些机制，因为在这些机制中有许多问题需要解决。例如，对活组织的安全性和可靠性尚不清楚。在我们的研究中，提出并研究并研究了基于超声波和微粒颗粒的使用的微观机制的支持。例如，当微粒悬浮在超声波站立波中时，站立波通过串起超声波的阶段横向移动时，微粒沿相同的侧向移动。这可能成为活组织中的微刮刀。如果微颗粒被超声驻波捕获，则拖放递送系统也可以以相同的方式设计。为了设计此类微型机制，包括微泵，微刮刀和微粒陷阱系统，提出了使用模拟血管和这些方法的特征进行基本实验。

项目成果

Y.Yamakoshi, et.al.: "Internal tissue displacement measurement based on ultrasonic wave Doppler signal digital detection" Ultrasonics. 12. 354-359 (1996)

Y.Yamakoshi 等人：“基于超声波多普勒信号数字检测的内部组织位移测量”超声波。

Y.Yamakoshi,et,al.: "Shear elastic measurement in vivo using ultrasonic imaging of internal forced low frequency vibration" Aconstical Imaging. 22. 293-298 (1996)

Y.Yamakoshi 等人：“使用内部受迫低频振动的超声成像进行体内剪切弹性测量”非视觉成像。

Y.Yamakoshi: "Measurement technique using ultrasonic radiation force to micro particle (in Japanese)" Japanese J.of Acoustical Society of Japan. 52,3. 210-216 (1996)

Y.Yamakoshi：“利用超声波辐射力对微粒进行测量的技术（日语）”日本声学学会杂志。

N. Shinozuka T Yamakoshi: "Transvaginal Sonographic Orientation Detection System using Ceramic Gyroscope" J. of Ultrasound in Med.15. 107-113 (1996)

N. Shinozuka T Yamakoshi：“使用陶瓷陀螺仪的经阴道超声方向检测系统”J. of Ultrasound in Med.15。

Y.Yamakoshi, et.al.: "Measurement of ultrasonic sound pressure from micro particle's locus observation insperiodically shifted ultrasonic standing wave (in Japanese)" Japanese J.of Acoustical Society of Japan. 52,1. 3-9 (1996)

Y.Yamakoshi 等人：“根据微粒轨迹观察不定期移动的超声波驻波测量超声波声压（日文）”日本声学学会杂志。