Detection of Spinal Cord Injury during Thoracoabdominal Aortic Aneurysm Surgery Using Multi-channel Superconducting Quantum Interference Device

多通道超导量子干涉仪检测胸腹主动脉瘤手术中脊髓损伤

• 批准号: 13557109
• 负责人: SUEDA Taijiro
• 金额: $ 6.98万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557109/
• 关键词: Spinal cord action magnetic field; Superconducting quantum interference device; SOUID; Evoked spinal cord potential; Magnetic shield room; Spinal cord ischemia; Aortic surgery; 筋電計

The main purpose of the current project was to test superconducting quantum interference device (SQUID), for detecting the spinal cord conduction and for predicting spinal cord ischemia. (1) Development of SQUID system for spinal cord study (at Hiroshima University) : Detection of spinal cord action magnetic field using one-channel SQUID failed. The limitation of the performance of the one-channel device was the profound cause of this failure. (2) Spinal cord ischemia model : Ischemia was induced in adult dogs by cross-clamping the thoracic aorta for 60 min.On April, 2002, we started to research using high performance 71-channel SQUID at NTT Docomo Multimedia Laboratories (Yokosuka, Japan). This multi-channel device has given results as follows. (3) Measurement of the peripheral compound nerve action magnetic field (CAF) and its spatial analysis : We succeeded in measuring the CAF of the human median and ulnar nerves. Nerve conduction was visualized by means of magnetography. (4) Magne … More tic analysis of ischemia-induced nerve conduction impairment : We succeeded in recording ischemic- changes of the median nerve conduction with magnetic study. Twenty -minute fore-arm ischemia was induced with the pneumatic tourniquet placing around the upper arm. The amplitude of the CAF of the median nerve significantly increased at 5 min after the initiation of ischemia, and it gradually decreased and almost completely disappeared at 20 min. Magnetographic evaluation also showed characteristic findings during early period of ischemia. (5) Development of multi -channel SQUID system for spinal cord study : A)-Spinal cord action magnetic field in rabbit ; We succeeded in visualization of ascending spinal cord conduction only in the lumbar area with magnetic study. B)-Dog study ; We failed to recording magnetic field of the canine cord because of insufficient sensor sensitivity. If this trouble is solved, we will apply an ischemia protocol for testing the current multi-channel device to detect spinal cord ischemia. Less

当前的量子干扰装置（squid）指示脊髓缺陷缺血模型：在成年犬中诱导您的胸腔主动脉60分钟。分析：我们成功地测量了人类中位数的CAF，通过磁性传导可视化。咖啡馆的局部缺血逐渐减少，并在20分钟内消失。带有磁性Y的绳索摩尔区域。检测脊髓绳索绳索缺血。

项目成果

山崎 健, 藤本吉範: "ラット胎仔の脊髄再生に関する実験的研究"広大医誌. 49・6. 189-204 (2002)

Ken Yamazaki，Yoshinori Fujimoto：“大鼠胎儿脊髓再生的实验研究”广岛大学医学杂志 49・6（2002）。

Sueda T et al.: "Selective intercostal arterial perfusion during thoracoabdominal aortic aneurysm surgery"Ann Thorac Surg. 70. 44-47 (2000)

Sueda T 等人：“胸腹主动脉瘤手术期间的选择性肋间动脉灌注”Ann Thorac Surg。

Sueda T et al.: "Evaluation of motor- and sensory-evoked potentials for spinal cord monitoring during thoracoabdominal aortic aneurysm surgery"Jpn J Thorac Cardiovasc Surg.. 48. 66-65 (2000)

Sueda T 等：“胸腹主动脉瘤手术期间脊髓监测的运动和感觉诱发电位的评估”Jpn J Thorac Cardiovasc Surg.. 48. 66-65 (2000)

末田泰二郎: "急性大動脈解離の診断と治療"臨床雑誌「外科」. 64巻10号. 1129-1132 (2002)

Taijiro Sueda：“急性主动脉夹层的诊断和治疗”临床杂志“Surgery”第64卷，第10. 1129-1132（2002年）。

田中信弘, 藤本吉範 他: "高齢者頚髄症に関する電気生理学的検討"脊髄電気診断学. 23. 52-56 (2001)

Nobuhiro Tanaka、Yoshinori Fujimoto 等：“老年人颈椎病的电生理学研究”《脊柱电诊断》23. 52-56 (2001)。