Detection of Spinal Cord Injury during Thoracoabdominal Aortic Aneurysm Surgery Using Multi-channel Superconducting Quantum Interference Device

多通道超导量子干涉仪检测胸腹主动脉瘤手术中脊髓损伤

基本信息

批准号：
13557109
负责人：
SUEDA Taijiro
金额：
$ 6.98万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

The main purpose of the current project was to test superconducting quantum interference device (SQUID), for detecting the spinal cord conduction and for predicting spinal cord ischemia. (1) Development of SQUID system for spinal cord study (at Hiroshima University) : Detection of spinal cord action magnetic field using one-channel SQUID failed. The limitation of the performance of the one-channel device was the profound cause of this failure. (2) Spinal cord ischemia model : Ischemia was induced in adult dogs by cross-clamping the thoracic aorta for 60 min.On April, 2002, we started to research using high performance 71-channel SQUID at NTT Docomo Multimedia Laboratories (Yokosuka, Japan). This multi-channel device has given results as follows. (3) Measurement of the peripheral compound nerve action magnetic field (CAF) and its spatial analysis : We succeeded in measuring the CAF of the human median and ulnar nerves. Nerve conduction was visualized by means of magnetography. (4) Magne … More tic analysis of ischemia-induced nerve conduction impairment : We succeeded in recording ischemic- changes of the median nerve conduction with magnetic study. Twenty -minute fore-arm ischemia was induced with the pneumatic tourniquet placing around the upper arm. The amplitude of the CAF of the median nerve significantly increased at 5 min after the initiation of ischemia, and it gradually decreased and almost completely disappeared at 20 min. Magnetographic evaluation also showed characteristic findings during early period of ischemia. (5) Development of multi -channel SQUID system for spinal cord study : A)-Spinal cord action magnetic field in rabbit ; We succeeded in visualization of ascending spinal cord conduction only in the lumbar area with magnetic study. B)-Dog study ; We failed to recording magnetic field of the canine cord because of insufficient sensor sensitivity. If this trouble is solved, we will apply an ischemia protocol for testing the current multi-channel device to detect spinal cord ischemia. Less

当前项目的主要目的是测试超导量子干扰装置（Squid），用于检测脊髓传导并预测脊髓缺血。（1）开发用于脊髓研究的鱿鱼系统（在广岛大学）：使用单通道鱿鱼检测脊髓动作磁场。单通道设备性能的局限性是这种失败的深刻原因。（2）脊髓缺血模型：成人犬的缺血是通过将胸腔主动脉交叉诱导的60分钟。2002年4月，我们开始使用NTT DOCOMO Multimedia Laboratories（日本Yokosuka）的NTT DOCOMO Multimedia实验室的高性能71-渠道鱿鱼进行研究。该多通道设备的结果如下。（3）测量周围化合物神经作用磁场（CAF）及其空间分析：我们成功地测量了人类中位和尺神经的CAF。神经传导是通过录像造影可视化的。（4）Magne…缺血诱导的神经传导障碍的更多抽动分析：我们成功地记录了通过磁性研究的中位神经传导的缺血变化。二十分钟的前臂缺血是通过气动止血带放置在上臂周围的。缺血开始后5分钟，中位神经CAF的放大器显着增加，并且在20分钟时逐渐改善，几乎完全消失。磁评估还显示出在缺血早期的特征发现。（5）开发用于脊髓研究的多通道鱿鱼系统：a）兔子中的脊髓动作磁场；我们仅通过磁研究才能在腰部区域内可视化升高的脊髓传导。 b）-Dog研究；由于传感器灵敏度不足，我们无法记录犬绳的磁场。如果解决了此问题，我们将应用缺血方案来测试当前的多通道设备以检测脊髓缺血。较少的