Study of underlying electrical pattern of chronic atrial fibrillation and development of new surgical radio-frequency ablation system

慢性心房颤动潜在电模式的研究及新型外科射频消融系统的开发

基本信息

批准号：
13470275
负责人：
SUEDA Taijiro
金额：
$ 5.44万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

We have performed intraoperative atrial mapping in the cases of atrial fibrillation (Af) associated with organic heart disease and analyzed electrophysiological and clinical data in last decade. In this study, we continued these investigations and developed new analysis methods.To visualize the electrophysiological characteristics, especially the "repetitive" and "frequent" activation, of chronic atrial fibrillation (Af) associated with or without organic heart disease, we mapped atrial electrical activity from atrial surface during atrial fibrillation by means of multi-point electrodes and specially made mapping system. Data were mainly acquired from the atrial free wall of both atria and anatomical obstacles, such as the orifice of pulmonary veins or crista terminalis, and were analyzed by specially designed software using spectrum analysis. Then we analyzed clinical outcome of pulmonary vein orifice isolation (PVO1), a less invasive simple surgical procedure that we developed and pe … More rformed, for chronic Af wilh the data from electrophysiological analysis. Moreover, we examined the delivery system of surgical radio frequency ablation with experimental and clinical analysis.Intraoperative visualization of repetitive activation of Af was useful for intraoperative decision of the ablation line. The results of analysis from clinical and electrophysiological data suggested that Af was highly diminished with PVO1, which showed more organic pattern in both atrial electric activation. The visualization mapping system can recognize the atrial organization. We believe that this outcome is useful for "Order Made Procedure" for chronic Af.Otherwise, we showed that the intraoperative radio frequency delivering was enough to create complete ablation line with the system now in use in the experimental and clinical study. However, we noted that low energy delivery possibly make incomplete block line. Then we supposed that the development of new ablation device for various block lines or for epicardial ablation is needed. Less

在过去的十年中，我们在与有机愈合的生物学和临床数据相关的心房繁殖（AF）的情况下，我们进行了磨损的映射。通过多点电极和特殊制作的映射，在纤颤期间与有机心脏映射的心脏映射的慢性心房颤动（AF）的“频繁”激活，主要是从心房和心房自由壁上获得的。解剖障碍物，例如肺静脉或CRISTA末端的孔口，并通过专门设计的软件分析了我们开发和PE的肺静脉孔分离（PVO1）的临床结果。此外，更富有成形的S.此外，外科无线电消融的传递系统具有经验和临床分析。对AF的重复激活的杂种性可用于术中决策，从临床和电生理数据的分析结果的术中决策中，表明AF用PVO1高度减少了AF在心房激活中显示了更多的有机模式。研究