Development of intraoperative measuring device for spinal cord potentials and prevetion of paraplegia during thoraoabdominal aortic surgery

术中脊髓电位测量装置的研制及胸腹主动脉手术中截瘫的预防

基本信息

批准号：
18390377
负责人：
SUEDA Taijiro
金额：
$ 10.43万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

The purpose of this study is to develop the device and procedure for trans-intercostal nerve evoked spinal cord potentials. We devised special electrodes to stimulate intercostals nerve and record spinal cord potebtials through intercostals nerve stimulation. We performed animal experiments of this electrode for trans-intercostal nerve evoked potentials using mongrel dogs and evaluated efficacy of this electrode to detect spinal cord potentials instead of motor evoked spinal cord potnetials. The results of this experiment are as follows1) In animal experiments using mongrel dogs, trans-intercostal nerve evoked spinal cord potentials showed accurate spinal cord electrogram, which was the same elecrogram as motor evoked spinal cord potentials. In addition, electrogram of trans-intercostal nerve evoked spinal cord potential was not effected by operative procedure and anesthesia.2) After animal experiments recording trans-intercostal nerve evoked spinal and potential, autopsy was performed The same region, in which trans-intercostal nerve evoked spinal cord potentials changed during aortic cross damping, involved critical interostals artery which supply spinal cord. We used red regin stain method to identify the critical Ma/pastels artery3) In clinical experiences, trans-intercostal nerve evoked spinal cord potentials could be detected in the intercostal nerves from Th7 to Th12. Trans-intercostal nerve evoked spinal cord potentials were taken very clearly and not influenced by anesthetic agents, including asipiratory and venous anesthetic agents. Trans-intercostal nerve evoked spinal cord potential could be used intraoperative monitoring of spinal cord ischemia instead of monitoring by motor and sensory evoked spinal cord potentials.

本研究的目的是开发经肋间神经诱发脊髓电位的装置和程序。我们设计了特殊的电极来刺激肋间神经，并通过刺激肋间神经来记录脊髓电位。我们使用杂种狗对该电极进行了跨肋神经诱发电位的动物实验，并评估了该电极检测脊髓电位而不是运动诱发脊髓电位的功效。本实验的结果如下： 1)在杂种狗的动物实验中，经肋间神经脊髓诱发电位显示出准确的脊髓电图，与运动诱发脊髓电位的电图相同。另外，跨肋神经脊髓电位电图不受手术操作和麻醉的影响。2）动物实验记录跨肋神经脊髓电位和电位后，进行尸检同一区域，其中跨肋神经主动脉交叉阻尼期间诱发的脊髓电位发生变化，涉及供应脊髓的关键骨间动脉。我们采用红色雷金染色法来识别关键的Ma/pastels动脉3)在临床经验中，在Th7至Th12的肋间神经中可以检测到经肋间神经诱发的脊髓电位。经肋间神经诱发脊髓电位测量非常清晰，不受麻醉剂（包括吸入麻醉剂和静脉麻醉剂）的影响。经肋间神经诱发脊髓电位可用于术中监测脊髓缺血，而不是通过运动和感觉诱发脊髓电位进行监测。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

脊髄誘発電位測定装置及び脊髄誘発電位測定システム

脊髓诱发电位测量装置及脊髓诱发电位测量系统

DOI：
发表时间：
2006
期刊：
影响因子：
0
作者：
通讯作者：

Transcranial motor-evoked potentials following intra-aortic cold blood infusion fascilitates detection of critical supplying artery of spinal cord

主动脉内冷血输注后的经颅运动诱发电位有助于检测脊髓的关键供应动脉

DOI：
发表时间：
2008
期刊：
Eur J Cardio Thorac Surg (In press)
影响因子：
0
作者：
Hamaishi;Makoto;Hamaishi Makoto
通讯作者：
Hamaishi Makoto

Evoked spinal cord potentials monitored at thoracoabdominal region after transintercostal stimulation

经肋间刺激后胸腹区脊髓诱发电位监测

DOI：
发表时间：
2006
期刊：
Hiroshim J Med Sci 55・2
影响因子：
0
作者：
Hamaishi;Makoto;Hamaishi Makoto;Miyazaki Masanori;Kumagai Hajime;Isaka Mitsuyoshi;Kumagai Hajime
通讯作者：
Kumagai Hajime

Cold spinoplegia and transverbral cooling pad reduce spinal cord injury during thoracoabdominal aortic surgery

冷脊髓麻痹和经椎冷却垫可减少胸腹主动脉手术期间的脊髓损伤