Development of low-cost optically pumped magnetometer system for fetal applications

开发用于胎儿应用的低成本光泵磁力计系统

• 批准号: 10589808
• 负责人: Hari Eswaran
• 金额: $ 37.3万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10589808
• 关键词: Abdomen; Algorithms; American Heart Association; Arkansas; Atrial Flutter; Atrial Premature Complexes; Attenuated; Beds; Biomedical Engineering; Brain; Breathing; Cardiac; Cardiac conduction system; Clinic; Complex; Data; Detection; Development; Diagnosis; Echocardiography; Electrocardiogram; Electrophysiology (science); Fetal Heart; Fetal Heart Rate; Fetal Monitoring; Fetal Movement; Fetal health; Fetus; Geometry; Gestational Age; Goals; Heart Abnormalities; Heart Block; Helium; Individual; Infrastructure; Intervention; Magnetism; Maintenance; Measures; Medical; Methods; Microfabrication; Modality; Mothers; Movement; National Institute of Biomedical Imaging and Bioengineering; Nervous System Trauma; Noise; Optics; Performance; Personal Satisfaction; Pilot Projects; Positioning Attribute; Pregnancy; Pregnant Women; Production; Pump; Research; Research Project Grants; Risk; Science; Shapes; Signal Transduction; System; Tachycardia; Techniques; Technology; Testing; Third Pregnancy Trimester; Translating; Universities; Uterus; Validation; acronyms; antenatal; clinical application; clinically relevant; cost; cryogenics; data quality; design; fetal; flexibility; heart rate variability; interest; magnetic field; manufacture; manufacturing technology; multidisciplinary; myometrium; pediatric cardiologist; postnatal; prenatal; reproductive; response; sensor; superconducting quantum interference device; time interval; tool; ultrasound

Abstract Currently, we can record non-invasive fetal magnetocardiographic (FMCG) signals with a magnetic sensor- based system called SARA (SQUID Array for Reproductive Assessment) installed at University of Arkansas for Medical Sciences. The study of the fetal heart, and in particular, the developing cardiac conduction system, has been significantly aided in the last two decades by the introduction of FMCG. The American Heart Association recently acknowledged the academic and clinic usefulness of this new modality. Several studies have shown that FMCG can provide new relevant clinical parameters for assessment of fetal cardiac activity and also supplement the parameters that are currently available. Despite all these benefits, the major hurdles facing SQUID technology include system and maintenance cost, cryogenic helium cooling, a rigid one-size-fits-all array, and a single position option for the mother. We have shown the feasibility of using uncooled biomagnetometer for potential prenatal assessments based on microfabricated optically-pumped magnetometers (OPM). The OPMs have many features similar to cryogenic SQUID-based systems as they measure the same field components, and are compatible with standard magnetically-shielded rooms. This proposal is in response to NIBIB’s PAR-19-158 Bioengineering Research Grants, where we apply a multidisciplinary integrative team approach to we plan to design, test and validate a 24-channel OPM sensor system that fits over the maternal abdomen. Performance of the OPM in a three-layered shielded room will be evaluated with respect to the data quality of FMCG signals which will be compared to those obtained from a gold standard SQUID based system. The overall goal is to demonstrate that with OPM systems (a) we can design a stand-alone flexible array for maternal-fetal application (b) record the desired biomagnetic signals equivalent to SQUID sensors; (c) be able to separate the signal into their constituents to extract FMCG and (d) quantify fetal heart signals and the relevant metrics. We believe that with potential lower costs and maintenance requirements, the benefits of using fetal biomagnetometery could be translated from the research to possible widespread clinical applications. The specific aims are as follows: Aim 1: Design and configure a bed-based stand-alone array of OPMs that conforms to the shape of the maternal abdomen in order to obtain signals with sufficient signal-to-noise ratio for fetal applications. Aim 2: Extract and quantify the FMCG waveform components to compute a) PQRS and T wave detection rates and cardiac time intervals (CTI). Aim 3: Record and characterize FMCG of fetuses that have been referred with abnormal heart conditions detected through routine ultrasound examination.

抽象的 目前，我们可以记录具有磁传感器的非侵入性胎儿磁性心脏图（FMCG）信号 基于阿肯色大学安装的基于SARA的系统（用于生殖评估的鱿鱼阵列） 医学科学。对胎儿心脏的研究，尤其是发育中的心脏传导系统 在过去的二十年中，他通过FMCG的推出得到了极大的帮助。美国心脏协会 最近承认这种新方式的学术和诊所有用性。几项研究表明 FMCG可以提供新的相关临床参数，以评估胎儿心脏活动以及 补充当前可用的参数。尽管所有这些好处，但面临的主要障碍 鱿鱼技术包括系统和维护成本，低温氦冷却，刚性的一定尺寸阵列， 以及母亲的单个职位选项。我们已经证明了使用未冷却的生物磁性计的可行性 对于基于微型光泵仪（OPM）的潜在产前评估。 OPM具有许多类似于低温鱿鱼系统的功能，因为它们测量了相同的领域 组件，并且与标准磁性房间兼容。该建议是对 尼比布的19-158届生物工程研究补助金，我们在其中应用多学科综合团队 我们计划设计，测试和验证24通道OPM传感器系统，该系统适合母亲 腹部。将对数据评估OPM在三层屏蔽室中的性能 FMCG信号的质量将与从基于黄金标准鱿鱼系统获得的信号进行比较。 总体目标是证明使用OPM系统（a）我们可以为独立的灵活阵列设计 产妇应用（b）记录所需的生物磁信号等于鱿鱼传感器； （c）能够 将信号分成其构成以提取FMCG和（d）量化胎儿心脏信号和相关的 指标。我们认为，由于潜在的成本和维护要求，使用胎儿的好处 生物磁法可以从研究转化为可能的宽度临床应用。 具体目的如下： AIM 1：设计和配置一个符合形状的基于床的独立阵列OPM 孕产妇的腹部以获取具有足够的胎儿应用信噪比比率的信号。 AIM 2：提取和量化FMCG波形组件以计算A）PQR和T波检测 率和心脏时间间​​隔（CTI）。 AIM 3：记录和表征以异常心脏条件转介的胎儿FMCG 通过常规超声检查检测。