Schistosomiasis haematobia - Studies on Hidden Morbidity

血吸虫病 - 隐藏发病率的研究

基本信息

批准号：
12576007
负责人：
AOKI Yoshiki
金额：
$ 9.73万
依托单位：
NAGASAKI UNVIERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

The morbidity due to Schisdaroma haematobium infection has been exclusively assessed by the examination of haematuria and ultrasound finding of bladder. However, the old papers have indicated that other organs are affected by S. haematobioum eggs. Recently our KAP (Knowledge, Attitudes and Practices) study suggested that the patients are suffering from the hidden morbidity such as bladder cancer. The present study was attempted to examine the incidence of bladder cancer, liver fibrosis and difficulty of urination in a community of the endemic areas of schistosomiasis haematobia in Kenya.Bladder cancer Urine cytology was performed to examine the incidence of bladder cancer among the villagers aged 20 years and over. Among 1516 individuals screened, positive cytology was detected in 4 persons and equivocal cytology was detected in 6 persons. This value is100 times as high as the incidence of bladder cancer in Japan.Liver fibrosis: Ultrasonographic investigation of liver was done in a community. For diagnosis of periportal thickening the 95^<th> percentile regarding peripheral portal vein branch diameter in the control group was used. Twenty-seven percent of the population had periportal thickening. Egg output and bladder wall morbidity were associated with an increased risk of periportal thickening.Difficulty of urination: International Prostate Symptom Score was used to examine the symptom of difficulty of urination: School boys in an endemic area were suffering from any symptoms of difficulty of urination. Uroflowmeter and ultrasound were used to examine the pattern of urination and residual urine. There was no difference in urination pattern between school boys living in endemic areas and those in non-endemic area. The results suggest that infected boys have no impediment in bladder function, although they complain of any symptoms of the difficulty of urination.

通过检查血尿和膀胱超声发现，已专门评估了由于血肿感染而引起的发病率。但是，旧论文表明其他器官受到Haematobioum卵的影响。最近，我们的KAP（知识，态度和实践）研究表明，患者患有隐藏的发病率，例如膀胱癌。本研究试图检查肯尼亚流行病地区血吸虫病血吸虫病流行病地区的膀胱癌，肝纤维化和排尿困难的发生率。进行了20岁及以上的村民的膀胱癌的发病率进行了膀胱癌的尿液细胞。在筛选的1516名个体中，在4人中检测到阳性细胞学，并在6人中检测到模棱两可的细胞学。该值与日本膀胱癌的发生率高达100倍。纤维化：肝脏的超声检查是在一个社区中进行的。为了诊断对照组中外周门静脉分支直径的95^<th>百分位的外周增厚。 27％的人口具有外围增厚。鸡蛋输出和膀胱壁发病率与增加外周增厚的风险增加有关。排尿困难：国际前列腺症状评分用于检查排尿困难的症状：处于地方性地区的男生患有任何排尿困难的症状。尿流计和超声检查用于检查排尿和残留尿液的模式。居住在流行地区的男生和非流行地区的男孩之间的排尿模式没有差异。结果表明，受感染的男孩对膀胱功能没有障碍，尽管他们抱怨了排尿困难的任何症状。