With the aim of early convalescence of the occlusal function in the immediate implant after tooth extraction :

为了使拔牙后即刻种植体的咬合功能尽早恢复：

基本信息

批准号：
12557162
负责人：
YOKOYAMA Atsuro
金额：
$ 5.57万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

The purpose of this study was to densify the sparse cancellous bone to achieve the early convalescence of the occlusal function in the immediate implant after tooth extraction. Firstly, we developed the calcium phosphate cement with the sufficient plasticity for easy molding into the desired shape. This cement had the good handling property and biocompatibility. Furthermore, we developed the sandwich technique and suggested that it was effective for the jaw bone augmentation. Although it was possible to make the calcium phosphate cement with porous structure, it was impossible to develop the calcium phosphate cement with bio-absorbability. It is necessary to make the cement with bio-absorbability for densification the cancellous bone. Therefore, we developed β-TCP-CM-chitin composite material that was injectable from the # 14 needle. No inflammatory response was observed when this composite was implanted in soft tissue and bone tissue. It showed this material had good biocompatibility. Active bone formation was observed in subcutaneous tissue when it was implanted with BMP. The problems such as BSE on the collagen are reported, while collagen was used for the carrier for BMP usual. It was suggested that this composite material was suitable for the carrier for BMP. Histological investigation was carried out to evaluate the effectiveness of this composite material as a bone substitute. At I week after implant, active bone formation was observed on the surface of the material. Absorption of the material and replacement to the bone was seen with time. It was showed that the cancellous bone was densified. These results suggested that the possibility of the early convalescence of the occlusal function in the immediate implant after tooth extraction.

本研究的目的是致密化稀疏的松质骨，以实现拔牙后即刻种植体咬合功能的早期恢复。首先，我们开发了具有足够可塑性的磷酸钙骨水泥，易于成型为所需形状。此外，我们开发了夹心技术，并表明它对于颌骨增量是有效的，尽管可以制造具有多孔结构的磷酸钙骨水泥。开发具有生物吸收性的磷酸钙骨水泥，使松质骨致密化是必要的，因此，我们开发了可从#14针注射的β-TCP-CM-甲壳素复合材料。将该复合材料植入软组织和骨组织时观察到炎症反应，表明该材料具有良好的生物相容性，在植入BMP时在皮下组织中观察到BSE等问题。报道了胶原蛋白，而胶原蛋白通常用作BMP的载体，因此进行了组织学研究以评估该复合材料作为骨替代物的有效性。植入后一周，在材料表面观察到活跃的骨形成，并随着时间的推移观察到骨的替换，这些结果表明早期的可能性。的康复期拔牙后即刻种植体的咬合功能。