Experimental Study on Immediate Extraction Implants : Application of the GTR Method with BMP to Immediate Extraction Implants

即刻拔牙种植体的实验研究：GTR方法与BMP在即刻拔牙种植体中的应用

• 批准号: 06671937
• 负责人: YOKOYAMA Atsuro
• 金额: $ 1.41万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671937/
• 关键词: BMP; GTR; immediate extraction implant; PTFE membrane; 骨形成タンパク質(BMP); 組織計量

The purpose of this study was to develop a new method for dental implant insertion. The possibility of applying of the GTR Method (Guided Tissue Regeneration) with a BMP-collagen complex to immediate extraction implants was investigated. Two beagles were used in this study. After extraction of P2, P3 and P4, a bone defect was made adjacent to the buccal aspect. The following treatments were investigated : an implant made from hydroxyapatite covered by a PTFE membrane (GTR group), an implant with BMP (BMP group), an implant with BMP covered by a PTFE membrane (BMP-GTR group) and only an implant (control group). The beagles were sacrificed 4 weeks after the operation. Histological and histometrical investigation were carried out to examine osteogenesis around the implants. The results of histometric measurements revealed that the percentage of implant surface in contact with bone in the bone defect was the highest in the BMP-GTR group, while the amounts of newly formed bone in the BMP-GTR and GTR groups were the same and significantly greater than the amounts in the BMP and control groups. The results showed that the application of the GTR Method with a BMP-collagen complex can be effectively applied to immediate extraction implants.

本研究的目的是开发一种新的牙种植体植入方法。研究了将 GTR 方法（引导组织再生）与 BMP-胶原蛋白复合物应用于即刻拔除植入物的可能性。本研究中使用了两只小猎犬。拔除 P2、P3 和 P4 后，在颊侧附近形成骨缺损。研究了以下治疗方法：由 PTFE 膜覆盖的羟基磷灰石制成的植入物（GTR 组）、带有 BMP 的植入物（BMP 组）、由 PTFE 膜覆盖的 BMP 植入物（BMP-GTR 组）和仅植入物（BMP-GTR 组）。对照组）。手术后4周处死小猎犬。进行组织学和组织计量研究以检查植入物周围的成骨作用。组织测量结果显示，骨缺损中种植体表面与骨接触的百分比在BMP-GTR组中最高，而BMP-GTR组和GTR组中新形成的骨量相同且显着大于 BMP 组和对照组的量。结果表明，GTR 方法与 BMP-胶原蛋白复合物的应用可以有效地应用于即刻拔牙种植体。