Research that factor and morbid state, of Congenital Chagas disease in South America

南美洲先天性恰加斯病的影响因素和发病状况研究

• 批准号: 13576011
• 负责人: TAKEUCHI Tsutomu
• 金额: $ 8.51万
• 依托单位: KEIO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13576011/
• 关键词: Congenital Chaga's disease; Bolivia; Northeast Brazil; Benznidazole; Splenomegaly; Triatoma; Trypanosoma cruzi; Chronic carrier; Bolivia; 媒介昆虫サシガメ; 先天性感染シャーガス病; P.C.R法; xenodiagnosis(媒介体診断); Benzonidazol; 慢性感染; Triatoma; アイソザイム解析; Xenodia

This study started with epidemiological research of congenital Chags' disease in Bolivia, but now evolve to all around in South America including Independencia area in Ceara state in Northeast Brazil. In Bolivia, we could follow up congenital Chagas' babies who had medicated Benznidazole for three years. After medication by Benznidazole, the pathogen disappeared from the blood of more than 95% of neonate, and swelling of the liver and splenomegaly could not be observed, either. But some were detected pathogen from their blood on the third year, we consider the reason uncompleted medication because the contact with the vector (Triatoma) could deny during their follow-up. It is clear that all of the congenital infected mothers are carriers (32/32), but the necessity of treatment has not been observed, so we need to spread knowledge to people including medical workers.From July 24 to 27 in 2003, Miura spoke about the above-mentioned at the 12th Convention Panamericans' NIKKEI-/Health Section (Aug-2003) in Santa Cruz, Bolivia, and apply for support to JICA Partnership Program. There's no case of congenital Chagas' disease in Northeast Brazil but chronic carriers are still exist and also the vector is still living there, so it is possible that this disease would spread as revival infection. The pathogens (Trypanosoma cruzi) which were isolated from the two countries' were different characteristic, we are evaluating about hereditary difference.

这项研究始于玻利维亚先天性chag病的流行病学研究，但现在演变为南美各地，包括巴西东北部的科拉州独立地区。在玻利维亚，我们可以跟进先天性木马的婴儿，这些婴儿服用了三年。在苯甲酸唑进行药物治疗后，病原体从超过95％的新生儿的血液中消失，肝脏和脾肿大的肿胀也无法观察到。但是，第三年从血液中发现了一些病原体，我们考虑了未完成的药物的原因，因为与载体（Triatoma）的接触在随访期间可能会否认。显然，所有被感染的母亲都是携带者（32/32），但是尚未观察到治疗的必要性，因此我们需要向包括医务人员在内的人传播知识。从2003年7月24日至27日，米拉（Miura）在2003年7月24日至27日都谈到了上述在第12次公约的Panamericans'Nikkei-nikkei-nikkei-nikkei-kei-iakica and juriakia and Jiaia and juia and juia and jiaia and Santa in santa in santa in santa in santa in santa in santa in topernive of。 程序。巴西东北部没有先天性查加斯疾病的情况，但慢性载体仍然存在，并且载体仍然生活在那里，因此这种疾病可能会随着复兴感染而传播。与两国分离的病原体（克鲁兹锥虫）的特征不同，我们正在评估遗传差异。

项目成果

Hamano Sinjiro: "Detection of kinetoplast DNA of Trypanosoma cruzi from dried feces of triatomine"Parasitology International. 50. 135-138 (2001)

Hamano Sinjiro：“从锥虫干粪便中检测克氏锥虫动质体 DNA”国际寄生虫学。

Higo Hiro: "The differences of genetic variation among major lineages in Trypanosoma cruzi"Abstracts of the 72th Annual Meeting of the Japanese Society of Parasitology. Suppl. 112 (2003)

Higo Hiro：“克氏锥虫主要谱系间遗传变异的差异”日本寄生虫学会第72届年会摘要。

Higo Hiro: "Phylogenetic distribution of Trypanosoma cruzi in South America"Abstracts of the 71th Annual Meeting of the Japanese Society of Parasitology. 157・II-D・29 (2002)

Higo Hiro：“南美克氏锥虫的系统发育分布”第71届日本寄生虫学会年会摘要157・II-D・29（2002年）。

Genetic variation among lineages of Trypanosoma cruzi and its geographic aspects.

克氏锥虫谱系间的遗传变异及其地理方面。

• 发表时间: 2004
• 期刊: Parasitology International 53
• 作者: Higo Hiroo;Miura Sachio;Takeuchi Tsutomu etc.
• 通讯作者: Takeuchi Tsutomu etc.

Triatomine bugs inhabiting housesin the state of Santa cruz-Bolivia and Northeast portions of Brazil and the infectionrate of Trypanosoma cruzi

玻利维亚圣克鲁斯州和巴西东北部地区房屋中的锥虫及克氏锥虫感染率

• 发表时间: 2005
• 期刊: Jap.Soc.Med.Ent & Zool (In press)
• 作者: Horio Masahiro;Miura Sachio;Takeuchi Tutomu etc.
• 通讯作者: Takeuchi Tutomu etc.