Long-term molecular epidemiological studies on thyroid cancers around Chernobyl

切尔诺贝利周围甲状腺癌的长期分子流行病学研究

基本信息

批准号：
19256003
负责人：
YAMASHITA Shunichi
金额：
$ 27.04万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

项目摘要

In order to clarify the direct cause of childhood thyroid cancers rapidly increased after the Chernobyl accident and its health consequences, we have successfully performed the joint research projects on molecular epidemiology on a basis of overseas' counterparts. Especially we could deeply commit to the international radiation safety programs with WHO, NCRP and EU and further deepened our understanding of radiation risk analysis and management with them. We have continued the collection of data on radiation-exposed victims and their biomaterials from the former USSR (Belarus, Ukraine and Russia), and extracted the DNAs which were subjected to further analysis of SNPs including the major target genes such as DNA damage repairing enzymes. Our results indicated the positive association of some SNPs pattern with radiation-associated thyroid cancers including DNA damage repairing enzymes and anti-oncogenes. Simultaneously we have worked at the Chernobyl Tissue Bank under the international … More consortium program. Using the samples collected from Chernobyl, we have analyzed the pathological changes of radiation-associated thyroid cancers and found the clinico-pathological characteristics such as genotype-phenotype difference by its different aged group, latency difference and histological difference. Fortunately there are no clinical prognostic difference between non-radiation and radiation-induced thyroid cancers at the standpoint of recurrence rate and mortality, suggesting a fairly good prognosis of childhood thyroid cancers after appropriate therapy. Now the genome wide association study is under investigation using the samples collected from Chernobyl.In conclusion, we have contributed to the revision of radiation safety guidelines on a basis of active participation on WHO and other international meetings using our own achievement. Besides the risk of external radiation exposure, internal exposure by radioactive iodines to neonate and children selectively and specifically increased the risk of radiation-induced thyroid cancers. Therefore our research progress can be expected to contribute to fundamental data on preventive measures of nuclear disaster and radiation safety standard guidelines that are also socially of a great significance. Less

为了阐明切尔诺贝利事故及其健康后果后童年甲状腺癌的直接原因迅速增加，我们在海外的同类产品的基础上成功地完成了有关分子流行病学的联合研究项目。尤其是我们可以通过WHO，NCRP和欧盟深深地致力于国际辐射安全计划，并进一步加深了我们对辐射风险分析和管理层的理解。我们继续收集了有关辐射暴露违规的数据及其从前苏联（白俄罗斯，乌克兰和俄罗斯）的生物材料，并提取了DNA，这些DNA受到对SNP的进一步分析，包括主要靶基因，包括主要靶基因，例如DNA损伤修复酶。我们的结果表明，某些SNP模式与辐射相关的甲状腺癌的正相关，包括DNA损伤修复酶和抗结构剂。同时，根据国际……更多的财团计划，我们曾在切尔诺贝利组织库工作。使用切尔诺贝利收集的样品，我们分析了与辐射相关的甲状腺癌的病理变化，并发现了临床病理学特征，例如基因型 - 表型差异，其不同的年龄群，潜伏期差异和组织学差异。幸运的是，在复发率和死亡率的角度，非放射性和辐射诱导的甲状腺癌之间没有临床预后差异，这表明经过适当的治疗后，对儿童期甲状腺癌的预后相当好。现在，使用切尔诺贝利收集的样本进行了研究，正在研究基因组广泛的研究。总之，我们为辐射安全指南的修订做出了贡献，基于积极参与谁和其他国际会议，使用我们自己的成就。除了出现外部辐射暴露的风险外，放射性碘的内部暴露于新生儿，儿童有选择地，特别明确地增加了辐射引起的甲状腺癌的风险。因此，可以预期我们的研究进度有助于有关核灾难和辐射安全标准指南的基本数据，这些数据在社会上也具有重要意义。较少的

项目成果

期刊论文数量（131）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Necessity of Radiation Emergency Medical Preparedness: Lessons Learned from Japans Experience.

辐射紧急医疗准备的必要性：日本经验教训。

DOI：
发表时间：
2008
期刊：
影响因子：
0
作者：
山下俊一;石原舜三;Shunichi Yamashita
通讯作者：
Shunichi Yamashita

Preoperative Diagnostics of Thyroid Nodules by Molecular Analysis of FNAB Materials

通过 FNAB 材料的分子分析对甲状腺结节进行术前诊断

DOI：
发表时间：
2009
期刊：
影响因子：
0
作者：
Mankovskaya S;Saenko V;Kartel N;Yamashita S.
通讯作者：
Yamashita S.

世界保健機関における内分泌代謝研究

世界卫生组织的内分泌代谢研究

DOI：
发表时间：
2008
期刊：
影响因子：
0
作者：
実松健造;村上浩康;渡辺寧;山下俊一
通讯作者：
山下俊一

The usual ultrasonographic features of thyroid cancer are less frequent in small tumors that develop after a long latent period after the Chernobyl radiation release accident.

甲状腺癌常见的超声检查特征在切尔诺贝利辐射释放事故后经过很长一段潜伏期后形成的小肿瘤中不太常见。

DOI：
发表时间：
2009
期刊：
Thyroid 19(7)
影响因子：
0
作者：
Drozd VM;Lushchik ML;Polyanskaya ON;Fridman MV;Demidchik YE;Lyshchik AP;Biko J;Reiners C;Shibata Y;Saenko VA;Yamashita S
通讯作者：
Yamashita S

Efficacy of Molecular Tests in Diagnosis of Papillary Thyroid Carcinoma.

分子检测在甲状腺乳头状癌诊断中的功效。