Long-term molecular epidemiological studies on thyroid cancers around Chernobyl

切尔诺贝利周围甲状腺癌的长期分子流行病学研究

基本信息

批准号：
19256003
负责人：
YAMASHITA Shunichi
金额：
$ 27.04万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

项目摘要

In order to clarify the direct cause of childhood thyroid cancers rapidly increased after the Chernobyl accident and its health consequences, we have successfully performed the joint research projects on molecular epidemiology on a basis of overseas' counterparts. Especially we could deeply commit to the international radiation safety programs with WHO, NCRP and EU and further deepened our understanding of radiation risk analysis and management with them. We have continued the collection of data on radiation-exposed victims and their biomaterials from the former USSR (Belarus, Ukraine and Russia), and extracted the DNAs which were subjected to further analysis of SNPs including the major target genes such as DNA damage repairing enzymes. Our results indicated the positive association of some SNPs pattern with radiation-associated thyroid cancers including DNA damage repairing enzymes and anti-oncogenes. Simultaneously we have worked at the Chernobyl Tissue Bank under the international … More consortium program. Using the samples collected from Chernobyl, we have analyzed the pathological changes of radiation-associated thyroid cancers and found the clinico-pathological characteristics such as genotype-phenotype difference by its different aged group, latency difference and histological difference. Fortunately there are no clinical prognostic difference between non-radiation and radiation-induced thyroid cancers at the standpoint of recurrence rate and mortality, suggesting a fairly good prognosis of childhood thyroid cancers after appropriate therapy. Now the genome wide association study is under investigation using the samples collected from Chernobyl.In conclusion, we have contributed to the revision of radiation safety guidelines on a basis of active participation on WHO and other international meetings using our own achievement. Besides the risk of external radiation exposure, internal exposure by radioactive iodines to neonate and children selectively and specifically increased the risk of radiation-induced thyroid cancers. Therefore our research progress can be expected to contribute to fundamental data on preventive measures of nuclear disaster and radiation safety standard guidelines that are also socially of a great significance. Less

为了弄清切尔诺贝利事故后儿童甲状腺癌迅速增加的直接原因及其健康后果，我们与海外单位成功开展了分子流行病学联合研究项目，特别是我们可以深入致力于国际辐射。我们与世界卫生组织、NCRP 和欧盟合作，进一步加深了我们对辐射风险分析和管理的理解。我们继续收集前苏联（白俄罗斯、乌克兰和俄罗斯）的辐射受害者及其生物材料的数据。提取的对这些 DNA 进行进一步的 SNP 分析，包括主要靶基因，例如 DNA 损伤修复酶，我们的结果表明一些 SNP 模式与辐射相关甲状腺癌（包括 DNA 损伤修复酶和抗癌基因）呈正相关。曾在国际联盟计划下的切尔诺贝利组织库工作，利用从切尔诺贝利收集的样本，我们分析了与辐射相关的甲状腺癌的病理变化，并发现了幸运的是，从复发率和死亡率的角度来看，非放射和放射诱发的甲状腺癌之间没有临床预后差异，例如不同年龄组的基因型-表型差异、潜伏期差异和组织学差异。目前，儿童甲状腺癌经过适当治疗后的预后相当好。目前，我们正在利用从切尔诺贝利收集的样本进行全基因组关联研究。总之，我们在积极参与世界卫生组织和其他组织的基础上，为辐射安全指南的修订做出了贡献。国际会议利用我们自己的成果，除了外部辐射暴露的风险外，放射性碘对新生儿和儿童的内部暴露也选择性地、特别地增加了辐射诱发的甲状腺癌的风险，因此我们的研究进展有望为预防措施的基础数据做出贡献。核灾难和辐射安全标准指南的制定也具有重要的社会意义。

项目成果

期刊论文数量（131）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

世界保健機関における内分泌代謝研究

世界卫生组织的内分泌代谢研究

DOI：
发表时间：
2008
期刊：
影响因子：
0
作者：
実松健造;村上浩康;渡辺寧;山下俊一
通讯作者：
山下俊一

The usual ultrasonographic features of thyroid cancer are less frequent in small tumors that develop after a long latent period after the Chernobyl radiation release accident.

甲状腺癌常见的超声检查特征在切尔诺贝利辐射释放事故后经过很长一段潜伏期后形成的小肿瘤中不太常见。

DOI：
发表时间：
2009
期刊：
Thyroid 19(7)
影响因子：
0
作者：
Drozd VM;Lushchik ML;Polyanskaya ON;Fridman MV;Demidchik YE;Lyshchik AP;Biko J;Reiners C;Shibata Y;Saenko VA;Yamashita S
通讯作者：
Yamashita S

甲状腺癌に関する基礎的研究「甲状腺細胞における癌化のメカニズム」

甲状腺癌基础研究“甲状腺细胞癌变机制”