Effects of medications on chronic pancreatitis in a rat model.

药物对大鼠模型慢性胰腺炎的影响。

• 批准号: 05671044
• 负责人: SUGIYAMA Masanori
• 金额: $ 1.34万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671044/
• 关键词: chronic pancreatitis; pancreatic exocrine function; protease inhibitor; animal model; chronic pancreatitis; pancreatic exocrine function; protease inhibitor; animal model

The effect of oral administration of protease inhibitor (camostat) on pancreatic morphology and exocrine function (conscious-rat model) was investigated using WBN/Kob rats with spontaneous chronic pancreatitis. In nontreated WBN/Kob rats (2 to 12 months of age), pancreatic fibrosis and parenchymal destruction compatible with human chronic pancreatitis appeared at 3 months and advanced with each month. Pancreatic secretion was markedly impaired at all ages. In WBN/Kob rats fed diets containing camostat (from 2 to 3, or from 4 to 5 months of age), the pancreas was hypertrophic but did not show any histological appearances compatible with chronic pancreatitis, and moreover, exocrine funciton was thoroughly restored with increased plasma cholecystokinin concentrations. Oral administration of protease inhibitor has both preventive and therapeutic effects on pancreatic lesions and dysfunction in an animal model of chronic pancreatitis, probably via endogenous cholecystokinin release.

使用带有自发性慢性胰腺炎的WBN/KOB大鼠研究了口服蛋白酶抑制剂（camostat）对胰腺形态和外分泌功能（有意识鼠模型）的影响。在未处理的WBN/KOB大鼠（2至12个月大）中，胰腺纤维化和实质破坏与人类慢性胰腺炎兼容，出现在3个月时，并且每个月都会前进。胰腺的分泌在各个年龄段都明显受损。在喂食含有果皮的饮食的WBN/KOB大鼠中，胰腺是肥大性的，但没有显示出与慢性胰腺炎兼容的任何组织学表现，而且外分泌funciton彻底恢复了血浆胆脂蛋白stokinsmakystokinin浓度。口服蛋白酶抑制剂对慢性胰腺炎动物模型中的胰腺病变和功能障碍具有预防和治疗作用，这可能是通过内源性胆囊动蛋白释放的。