Treatment of heart failure, cardiac hypertrophy, and fatal arrhythmia by ryanodine receptor-bound calmodulin regulation

通过兰尼定受体结合钙调蛋白调节治疗心力衰竭、心脏肥大和致命性心律失常

• 批准号: 20H03677
• 负责人: YANO MASAFUMI
• 金额: $ 11.4万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20H03677/
• 关键词: 心不全; 致死的不整脈; リアノジン受容体; カルモジュリン; ダントロレン

项目成果

Stabilization of RyR2 maintains right ventricular function, and improves prognosis in pulmonary hypertension

RyR2 的稳定可维持右心室功能并改善肺动脉高压的预后

• 发表时间: 2021
• 作者: Shinji Tanaka;Takeshi Yamamoto;Junya Nawata;Shohei Fujii; Yoshihide Nakamura;Michiaki Kohno; Hitoshi Uchinoumi;Tetsuro Oda;Shigeki Kobayashi;Masafumi Yano
• 通讯作者: Masafumi Yano

Enhanced oxidative stress and presence of ventricular aneurysm for risk prediction in cardiac sarcoidosis.

• DOI: 10.1136/heartjnl-2021-320244
• 发表时间: 2022-03
• 期刊: Heart (British Cardiac Society)
• 作者: Yoshitomi R;Kobayashi S;Yano Y;Nakashima Y;Fujii S;Nanno T;Ishiguchi H;Fukuda M;Yoshiga Y;Okamura T;Suga K;Kawano R;Yano M
• 通讯作者: Yano M

Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice

用丹曲林治疗稳定心脏兰尼碱受体可预防压力超负荷心力衰竭小鼠的左心室重构

• DOI: 10.1016/j.bbrc.2022.12.063
• 发表时间: 2023
• 期刊: Biochemical and Biophysical Research Communications
• 影响因子: 3.1
• 作者: Yano Yasutake;Kobayashi Shigeki;Uchida Tomoyuki;Chang Yaowei;Nawata Junya;Fujii Shohei;Nakamura Yoshihide;Suetomi Takeshi;Uchinoumi Hitoshi;Oda Tetsuro;Yamamoto Takeshi;Yano Masafumi
• 通讯作者: Yano Masafumi

Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells

内质网应激促进钙调蛋白核转位，从而激活血管平滑肌细胞的表型转换

• DOI: 10.1016/j.bbrc.2022.08.069
• 发表时间: 2022
• 期刊: Biochemical and Biophysical Research Communications
• 影响因子: 3.1
• 作者: Uchida Tomoyuki;Oda Tetsuro;Yamamoto Takeshi;Inamitsu Masako;Sakai Chihiro;Uchinoumi Hitoshi;Suetomi Takeshi;Nakamura Yoshihide;Okamoto Yoko;Tateda Satomi;Fujii Shohei;Tanaka Shinji;Nawata Junya;Okamura Takayuki;Kobayashi Shigeki;Yano Masafumi
• 通讯作者: Yano Masafumi

RyR2-targeting therapy improves left ventricular remodeling after myocardial infarction

RyR2 靶向治疗改善心肌梗死后左心室重构

• 发表时间: 2021
• 作者: 藤井翔平;小林茂樹;矢野雅文
• 通讯作者: 矢野雅文