Interfacial effects and ingrowing behavior of magnesium-based foams as bioresorbable bone substitue material

镁基泡沫作为生物可吸收骨替代材料的界面效应和向内生长行为

• 批准号: 271761343
• 负责人: Professor Dr.-Ing. Hans Jürgen Maier
• 金额: --
• 依托单位: Institut für Werkstoffkunde (IW)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/271761343?language=en
• 关键词: Interfacial; effects; ingrowing; behavior; magnesium

Magnesium-based alloys as absorbable implants for osteosynthesis are still in the focus of national and international research groups. Previous in vitro and in vivo studies demonstrated good biocompatibility. Furthermore, it has been shown that individual alloy compositions have an influence on the corrosion process. The aim of this proposal is, to study a biodegradable bone substitute based on LAE442- and MgLa2 alloys with (two different) open porous geometries and three different coatings. The scaffolds will be tested in the non-loaded and in the loaded cancellous bone. The interactions between Mg-scaffolds, coatings and host tissue in relation to biomechanics, biocompatibility and degradation will be thoroughly investigated. Furthermore, the cellular reactions within the bone substitutes will be evaluated and new bone formation will be examined histomorphometrically. Based on the results of these studies, the implant structure will be modified. Initially, these studies will be executed in an established rabbit model to obtain preliminary results. Based on those findings and after optimization of all experimental settings, additional studies will be carried out in a sheep model representative for human bone.

基于镁的合金作为骨合成的可吸收植入物仍处于国家和国际研究小组的重点。先前的体外和体内研究表现出良好的生物相容性。此外，已经表明单个合金组成对腐蚀过程有影响。该提案的目的是研究基于LAE442-和MGLA2合金的可生物降解骨替代品，并具有（两种不同的）开放多孔几何形状和三种不同的涂层。脚手架将在未加载的和负载的取消骨骼中进行测试。与生物力学，生物相容性和降解相关的MG量，涂层和宿主组织之间的相互作用将得到彻底研究。此外，将评估骨骼替代物中的细胞反应，并将通过组织形成检查新的骨形成。根据这些研究的结果，将修改植入物结构。最初，这些研究将在既定的兔子模型中执行以获得初步结果。根据这些发现并在所有实验环境进行了优化之后，将在代表人骨的绵羊模型中进行其他研究。