NSF PRFB FY23: Effects of bioengineering on community assembly and ecosystem functioning in a soil microbial community

NSF PRFB FY23：生物工程对土壤微生物群落的群落组装和生态系统功能的影响

• 批准号: 2305961
• 负责人: Callie Chappell
• 金额: $ 24万
• 依托单位: Chappell, Callie Rodgers
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2305961&HistoricalAwards=false
• 关键词: NSF; PRFB; FY23; Effects; bioengineering; NSF; PRFB; FY23; Effects; bioengineering

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2023, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment, and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. Current trends in the development of new products and technologies may lead to the release of bioengineered organisms into the environment. While much work is done to develop such technologies, their environmental effects get less attention. More work is needed to understand and predict the impacts of bioengineered organisms. In this proposal, the Fellow will study how bioengineered organisms affect the environment by studying their DNA, traits, and interactions with other organisms. This research will involve high school interns, agricultural laborers, and artists. The purpose of the work is to develop a fairer approach to bioengineering, making sure that the development of such technology considers both people and the planet.The fellow will use a combination of engineering, experimental, and observational approaches to describe the effects of introduced genetic variation on population-level traits, community stability, and ecosystem functioning. This project investigates a Rule of Life (RoL) by connecting the mechanistic relationships between genomes and phenomes of bioengineered organisms to ecological processes such as community assembly and ecosystem functioning. Using a system of plant-associated soil microbes, the fellow will use genetic engineering to create microbial consortia and study its effects on community and ecosystem processes. The research will show whether individual genetic changes affect community assembly and ecosystem functioning in this system. Results will advance theoretical predictions about the effects of extreme trait variation on ecological and evolutionary processes. The fellow seeks to expand participation in STEM research and education through collaborating with youth interns and working with local non-profits in the greater Bay Area of California.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动为2023财年生物学的NSF博士后研究奖学金提供了资金，该研究综合研究调查了有关基因组，环境和表型之间相互作用的生活规则。奖学金支持对研究员的研究和培训，这些研究和培训将以创新的方式为生活规则做出贡献。新产品和技术开发的当前趋势可能会导致生物工程生物释放到环境中。尽管正在开发此类技术的许多工作，但它们的环境效应受到了较少的关注。需要更多的工作来了解和预测生物工程生物的影响。在这一提议中，研究员将通过研究其DNA，特征和与其他生物体的相互作用来研究生物工程的生物如何影响环境。这项研究将涉及高中实习生，农业劳工和艺术家。这项工作的目的是开发一种更公平的生物工程方法，以确保这种技术的发展考虑了人和地球。该研究员将使用工程，实验和观察方法的结合来描述引入遗传变异对人口水平特征，社区稳定性以及生态系统功能的影响。该项目通过将基因组与生物工程生物现象之间的机械关系与生态过程（例如社区组装和生态系统功能）联系起来来研究生命规则（ROL）。研究员将使用与植物相关的土壤微生物系统，将使用基因工程来创建微生物联盟并研究其对社区和生态系统过程的影响。该研究将表明，单个遗传变化是否会影响该系统中社区组装和生态系统的功能。结果将推进有关极端性状变化对生态和进化过程的影响的理论预测。该研究员试图通过与青年实习生合作并与加利福尼亚州大湾地区的当地非营利组织合作扩大参与STEM研究和教育的参与。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子的评估来支持的，并具有更广泛的影响。