Collaborative Research: SCH: A wireless optoelectronic implant for closed-loop control of bi-hormone secretion from genetically modified islet organoid grafts

合作研究：SCH：一种无线光电植入物，用于闭环控制转基因胰岛类器官移植物的双激素分泌

• 批准号: 2306708
• 负责人: Wen Li
• 金额: $ 84万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2306708&HistoricalAwards=false
• 关键词: Collaborative; Research; SCH; wireless; optoelectronic

Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1.5 million Americans and 20–40 million people worldwide. While a broad understanding of T1D has been gained over the past few decades, a cure for T1D is still not available. Researchers at Michigan State University and the University of Texas at Austin are collaborating to develop a novel framework for continuous, precise, and closed-loop control of bi-hormone (insulin or glucagon) secretion, using tiny wireless optoelectronic implants. This research is the first attempt to use optogenetic tools, using an array of highly efficient, implantable, Wireless (untethered and battery-free) OptoElectronic Implants (WOEIs) with a negligible footprint and minimal invasiveness to control bi-hormone secretion from islet organoids. This approach should pave the way for developing a new technological therapy for T1D. The direct benefits to millions of affected individuals worldwide include improved quality of life and reduced cost of associated medical care.The overarching goal of this project is to develop a closed-loop framework for rapid, selective, and precise control of bi-hormone secretion from genetically modified islet organoid grafts, using highly efficient, implantable WOEIs. The WOEI will monolithically integrate a dual-color optical stimulator and an optical glucose sensor with a wireless system-on-chip in an ultra-small and lightweight package. A distributed array of such WOEIs can simultaneously control many islet organoids for large volumetric coverage and better uniformity. A wireless backpack worn by the animal will carry highly efficient wireless electronics for safe power transfer from a wireless power cage to the WOEIs, and wideband data communication with the WOEIs and with the end-user. An interactive user interface hosted on a personal device (i.e., personal computer, smartphone, etc.) will receive and analyze glucose-sensing data in real-time and control optogenetic modulation in a closed-loop manner. This project is multidisciplinary and will significantly impact research and technological development in biomedical devices, stem cell biology, and wireless microelectronics. Furthermore, this project is expected to have a broad impact on engineering-/health-related STEM education through the integration of research with diverse educational and outreach activities, such as project demos/field tours, graduate and undergraduate research, teacher training, K-12 curricula, new course components, social media, and YouTube programs. These efforts will collectively benefit the broader society by providing effective personalized therapies for T1D management, engaging significant underserved populations, promoting biomedical research for personalized medicine, and training the US STEM workforce.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

1 型糖尿病 (T1D) 是一种慢性自身免疫性疾病，影响着 150 万美国人和全世界 20-4000 万人，尽管在过去几十年中人们对 T1D 有了广泛的了解，但仍然没有治愈 T1D 的方法。密歇根州立大学和德克萨斯大学奥斯汀分校正在合作开发一种新颖的框架，利用微型无线技术对双激素（胰岛素或胰高血糖素）分泌进行连续、精确和闭环控制这项研究是使用高度光遗传学工具的首次尝试，使用一系列高效、可植入、无线（不受束缚且无电池）的光电植入物（WOEI），其占地面积可忽略不计且侵入性极小，以控制双激素的分泌。这种方法应该为开发 T1D 新技术疗法铺平道路，为全球数以百万计的患者带来直接好处，包括提高生活质量和降低成本。该项目的首要目标是开发一个闭环框架，使用高效、可植入的 WOEI 来快速、选择性和精确地控制转基因胰岛类器官移植物的双激素分泌。将双色光学刺激器和光学葡萄糖传感器与无线片上系统集成在超小型和轻量级封装中，此类 WOEI 的分布式阵列可以同时控制许多胰岛类器官。动物佩戴的无线背包将携带高效的无线电子设备，以实现从无线电源笼到 WOEI 的安全电力传输，以及与 WOEI 和最终用户的宽带数据通信。个人设备（即个人电脑、智能手机等）上托管的用户界面将实时接收和分析葡萄糖传感数据，并以闭环方式控制光遗传学调制。该项目是多学科的，将显着。此外，该项目预计将通过将研究与各种教育推广活动相结合，对工程/健康相关的 STEM 教育产生广泛的影响。项目演示/实地考察、研究生和本科生研究、教师培训、K-12 课程、新课程组成部分、社交媒体和 YouTube 项目这些努力将通过为 T1D 管理提供有效的个性化治疗、吸引大量服务不足的人员，共同造福更广泛的社会。人口，促进该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。