FORce-Mediated Cognition by Exercise (FORCE)

力介导的运动认知 (FORCE)

• 批准号: 2342257
• 负责人: Taher Saif
• 金额: $ 71.55万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2342257&HistoricalAwards=false
• 关键词: FORce; Mediated; Cognition; Exercise; FORCE

Regular aerobic exercise, such as fast walking 40 minutes per day, helps maintain cognitive health, even at late stages of life. With ageing, the volume of the hippocampus- part of the brain attributed to memory and learning, decreases. Exercise not only prevents this loss in volume, but increases the volume due to new neurons, and other brain cell. Biochemicals released by exercising muscle likely support this growth. But how they influence hippocampal cells remains a mystery. This project supports research that attempts to resolve this enigma by considering a transformative new paradigm wherein muscle contraction during exercise is transduced to contraction of hippocampal cells themselves. The results from the study may lead to reverse-engineering of pathologies, such as e.g., Alzheimer’s disease, depression, and anxiety that result in a diminished size and function of the hippocampus. The project is based on the hypothesis that exercising muscle makes hippocampal cells contractile, and that this contractility results in new neurons from brain stem cells. The hypothesis is based on preliminary findings in the PIs’ labs. The hypothesis will be tested by exercising mouse muscle tissue cultured on a petri dish. The biochemicals released by the exercising muscle tissue will be provided to mouse hippocampal cells extracted from mouse brain cultured on a dish. The effect of exercise on brain cells will be evaluated by measuring brain cell contractility and formation of new neurons on the dish. The hypothesis will also be tested in running and sedentary mice by quantifying relative expressions of brain proteins known to be responsible for cell contractility. The results of the study will be disseminated to the public through (1) exercise-brain presentations to diverse elderly populations; (2) development of a 5-part video series on exercise-brain interactions for social media; (3) Involvement of high school and undergraduate students in the exercise-brain research; and (4) presentations at the local library, campus open house, farmers market and local schools.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

定期的有氧运动，例如每天快速步行40分钟，即使在生活的后期，也有助于保持认知健康。随着衰老的衰老，归因于记忆和学习的大脑的海马体积进展。运动不仅可以防止这种体积损失，还可以增加由于新神经元和其他脑细胞引起的体积。通过锻炼肌肉释放的生化物可能支持这种增长。但是它们如何影响海马细胞仍然是一个谜。该项目支持试图通过考虑变革性的新范式来解决这种谜的研究，其中运动过程中的肌肉收缩被转化为海马细胞本身的收缩。该研究的结果可能导致病理的反向工程，例如阿尔茨海默氏病，抑郁和焦虑，导致海马的大小和功能减少。该项目基于以下假设：锻炼肌肉使海马细胞收缩，并且该收缩力导致脑干细胞的新神经元。该假设基于PIS实验室中的初步发现。该假设将通过在培养皿上培养的运动小鼠肌肉组织来检验。运动肌肉组织释放的生化物将被提供给从培养在盘子上培养的小鼠大脑中提取的小鼠海马细胞。锻炼对脑细胞的影响将通过测量脑细胞收缩力和盘子上新神经元的形成来评估。该假设还将通过量化已知负责细胞收缩力的脑蛋白的相对表达来在跑步和久坐小鼠中进行检验。这项研究的结果将通过（1）对较早人群的潜水员的运动表现传播给公众； （2）开发有关社交媒体锻炼互动的5部分视频系列； （3）高中和本科生参与运动 - 脑研究； （4）在当地图书馆，校园开放日，农贸市场和当地学校的演讲。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响评估标准，被视为通过评估而被视为珍贵的支持。