MRI: Track 1 Acquisition of a 500 MHz solid/liquid-state NMR to Expand Interdisciplinary Research and Education at Howard University

MRI：第一轨道采购 500 MHz 固态/液态 NMR 以扩大霍华德大学的跨学科研究和教育

• 批准号: 2320489
• 负责人: Steven Cummings
• 金额: $ 109万
• 依托单位: Howard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320489&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; 500; MHz

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Howard University is acquiring a 500 MHz solution and solid-state Nuclear Magnetic Resonance (NMR) spectrometer equipped with a broadband probe and a triple-resonance solids probe to support the research of Professor Steven Cummings along with colleagues Amol Kulkami, Dharmaraj Raghavan, Sung Kim, and Timothy Ramadhar. This instrument facilitates research in the areas of catalyst design, biochemistry, polymer chemistry, nanomaterials, and medicinal chemistry. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and research training at all levels in multiple departments at Howard University, a Historically Black University (HBCU). This instrument further propagates research and educational opportunities between the Minority-Serving Institutions in the region including Morgan State University, Bowie State University, and Gallaudet University. The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as characterizations of metal-organic frameworks, biological systems and materials, and nanoparticles. Specifically, the instrument impacts research focused on fusing carborane chemistry with carbene and pyridinate ligands. The instrument is also used for structural investigations of complex bioactive compounds by structural and mechanistic analysis of the crystalline sponge method. Additionally, this instrument enables the composition analysis of Staphylococcus aureus biofilm. Other investigations include the metabolome and composition analysis of exosome in search of markers for Type 1 diabetes, and the determination of the binding mode of small molecules to the protein NLRP3 inflammasome. In response to global helium supply challenges and the 2022 CHIPS and Science Act, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具和化学研究工具计划共同支持。霍华德大学（Howard University）购买了配备宽带探针和三重共振固体探针的500 MHz解决方案和固态核磁共振仪（NMR）光谱仪，以支持史蒂芬·卡明斯（Steven Cummings）教授与同事Amol Kulkami教授的研究该仪器促进了催化剂设计，生物化学，聚合物化学，纳米材料和医学化学领域的研究。通常，NMR光谱是化学家可用的最强大工具之一，用于阐明分子结构。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。该工具可以在霍华德大学（HBCU）的霍华德大学多个系的各个级别的教育，研究和研究培训。该工具进一步传播了该地区少数派服务机构（包括摩根州立大学，鲍伊州立大学和加洛德大学）之间的研究和教育机会。 500 MHz NMR光谱仪的奖励旨在增强各个级别的研究和教育，尤其是在金属有机框架，生物系统和材料以及纳米颗粒等领域。具体而言，该仪器影响研究的重点是将碳烷化学与碳烯和吡啶酸配体融合。该仪器还用于通过晶体赞助商方法的结构和机械分析进行复杂的生物活性化合物的结构投资。此外，该仪器可实现金黄色葡萄球菌生物膜的组成分析。其他研究包括用于寻找1型糖尿病标记的外泌体的代谢组和组成分析，以及测定小分子与蛋白质NLRP3炎性体的结合模式。为了应对全球氦气供应挑战和2022 CHIPS和科学法，该乐器的获取包括一个超导磁铁，低损失低温恒温器减少了该机构对氦气的消费。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子功能和广泛的影响来评估NSF的法定任务。