MRI: Track 1 Acquisition of a Single-Crystal X-ray Diffractometer to Support Primarily Undergraduate Research in the Greater Susquehanna Valley

MRI：轨道 1 采购单晶 X 射线衍射仪，主要支持大萨斯奎哈纳山谷的本科生研究

• 批准号: 2320461
• 负责人: William Dougherty
• 金额: $ 20.02万
• 依托单位: Susquehanna University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320461&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Single; Crystal; MRI; Track; Acquisition; Single; Crystal

This award is jointly supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) programs. Susquehanna University is acquiring a diffractometer with a sealed-tube copper X-ray source, a charge-integrated pixel array detector and a liquid-nitrogen-fueled low temperature cooling device to support the research of William Dougherty Jr. (Susquehanna University), Brian Smith (Bucknell University), and colleagues at both institutions. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact many areas, including organic and inorganic chemistry, catalysis, and materials chemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate master’s students in multiple disciplines including chemistry and biochemistry at these institutions. The instrument will serve as a regional resource for the greater Susquehanna valley benefiting faculty and students at additional primarily undergraduate institutions including collaborative efforts with Lycoming College, Elizabethtown College, and Wilkes University. The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on the synthesis, structure determination, and applications of small molecules, covalent organic frameworks (COFs), nanomaterials, and supramolecular structures. The supported research will advance the fundamental understanding of synthetic pathways, aid in the development of new therapeutic platforms and imaging agents, provide insight into the varied mechanisms of crystal growth and explore the relationship between small-molecule design and the resulting electronic and structural properties. The compounds under investigation have applications in material science including the development of new catalysts, specialized filtration, the generation of more efficient photovoltaic devices and the creation of selective chemical sensors. Other proposed projects have applications in the field of medicine through the generation of complexes with anti-bacterial, anti-inflammatory and anti-cancer properties, efficient contrast agents for imaging, and improving crystallization approaches in pharmaceutical formulation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究工具（MRI）和化学研究工具（CRIF）计划共同支持。 Susquehanna University正在购买带有密封管铜X射线源的衍射仪，电荷集成像素阵列探测器和液氮燃料的低温冷却装置，以支持William Dougherty Jr.（Susquehanna University），Brian Smith（Bucknell University）以及两种设备的联盟。通常，X射线衍射仪可以准确，精确地测量分子的完整三维结构，包括键距离和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。此处描述的研究将影响许多领域，包括有机和无机化学，催化和材料化学。该乐器是教学的组成部分，也是对这些机构的化学和生物化学在内的多个学科的本科生和研究生硕士学生的研究和研究培训。该乐器将作为大型萨斯奎哈纳山谷（Greater Susquehanna Valley）的区域资源，使教师和学生在其他小学本科机构中受益匪浅，包括与Lycoming College，Elizabethtown College和Wilkes University的合作努力。该奖项旨在增强各级研究和教育。该仪器启用的研究集中在小分子，共价有机框架（COF），纳米材料和超分子结构的合成，结构测定和应用上。支持的研究将提高人们对合成途径的基本理解，有助于开发新的治疗平台和成像剂，可深入了解晶体生长的各种机制，并探索小分子设计与产生的电子和结构特性之间的关系。所研究的化合物在材料科学中有应用，包括开发新催化剂，专业过滤器，更有效的光伏设备的产生以及选择性化学传感器的创建。其他提议的项目通过产生具有抗细菌，抗炎和抗癌特性的复合物，在医学领域中应用，有效的对比剂进行了成像，并改善了药物制定中的结晶方法。该奖项颁发了NSF的法定任务，反映了通过评估的智力效果，并反映了基金会的支持。