MRI: Track 1 Acquisition of a 400 MHz NMR Spectrometer to Advance Undergraduate Research and Training

MRI：轨道 1 采购 400 MHz NMR 波谱仪以推进本科生研究和培训

• 批准号: 2319929
• 负责人: Miriam Bowring
• 金额: $ 42.47万
• 依托单位: Reed College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2319929&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; 400; MHz

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Reed College is acquiring a 400 MHz NMR spectrometer equipped with a broadband probe to support the research of Professor Miriam Bowring along with colleagues Shivani Ahuja and Gonzalo Campillo-Alvarado. This instrument facilitates research in the areas of synthetic chemistry, biochemistry, and catalysis. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels in the Chemistry Department at Reed College and enables increased diverse representation of high school teachers and students through established outreach programs.The award of the 400 MHz NMR spectrometer is aimed at enhancing undergraduate research and education at all levels, especially in areas such as mechanistic organometallic catalysis, metal ion transporter proteins, and synthesis of molecular sensors. Specifically, the instrument impacts research focused on understanding new mechanisms in synthetic organometallic chemistry of a platinum methyl complex and a bimetallic iridium-ruthenium catalyst. Additionally, the instrument enables the characterization of small molecule binders of bacterial ATP-binding cassette transporter proteins. Other investigations include characterizing the supramolecular confinement of petrochemicals using dynamic crystalline frameworks for sensing and separating complex chemical mixtures. In response to global helium supply challenges, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目共同支持，里德学院正在购买一台配备宽带探头的 400 MHz 核磁共振波谱仪，以支持 Miriam Bowring 教授及其同事 Shivani Ahuja 和 Gonzalo Campillo-Alvarado 的研究。该仪器促进了合成化学、生物化学和催化领域的研究。 一般来说，核磁共振 (NMR) 光谱是其中之一。它是化学家阐明分子结构的最强大工具，可用于识别未知物质、表征分子内原子的特定排列以及研究溶液或固态中分子之间相互作用的动力学。使用最先进的核磁共振波谱仪对于进行前沿研究的化学家来说至关重要。该仪器增强了里德学院化学系各级学生的教育、研究和教学工作，并提高了化学家的多样性。中学400 MHz 核磁共振波谱仪的获奖旨在加强各级本科生的研究和教育，特别是在机械有机金属催化、金属离子转运蛋白和分子传感器合成等领域。该仪器影响的研究重点是了解铂甲基络合物和双金属铱-钌催化剂的合成有机金属化学的新机制。此外，该仪器还能够表征小分子。其他包括使用动态晶体框架来表征石化产品的超分子限制，以应对全球氦气供应挑战。低损耗低温恒温器减少了机构的氦气消耗。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查进行评估，被认为值得支持标准。