RUI: CAS-SC: Promoting Group-Transfer Reactions at Metal/Main-Group Bonds

RUI：CAS-SC：促进金属/主族键的基团转移反应

• 批准号: 2244969
• 负责人: Matthew Whited
• 金额: $ 35.59万
• 依托单位: Carleton College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2244969&HistoricalAwards=false
• 关键词: RUI; CAS; SC; Promoting; Group

With support from the Chemical Synthesis Program of the Chemistry Division, Matthew T. Whited and his research group of undergraduate students at Carleton College are developing new applications of metal complexes featuring bonds to heavy non-metal elements such as silicon. These compounds are designed to provide synergistic interaction between the main group atom and the metal. This enables the compound to bring together different groups and enable reactions between them. The project will develop systems where reactive chemical fragments are attached to inexpensive and readily abundant substrates to afford products with applications in both that bulk and fine chemical arenas. This approach also seeks to replace expensive, rare metals with earth abundant ones in catalysis. The project will provide a training ground for undergraduate researchers and enable expanded outreach to high school students in Northfield, MN and Faribault, MN on topics related to chemical synthesis and X-ray crystallography.This project seeks to develop the chemistry of late-metal/main-group interactions by exploring metal-silicon single and multiple bonds as platforms for transfer of reactive nitrene, carbene, and related groups to organic substrates. Preliminary findings have shown that these “electronically frustrated” linkages can enable dual-site catalysis whereby the two sites (metal and main-group element) interact with different substrates to bring them together, but the generality of this strategy has not been demonstrated. Such an approach serves to avoid problems of poisoning present in many catalysts and also provides a distinct approach to using earth abundant metals such as iron, cobalt, and nickel in group-transfer catalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学部的化学合成计划的支持下，卡尔顿学院的Matthew T. Whitened及其本科生的研究小组正在开发新的金属综合体应用，这些金属综合体具有与硅等重型非金属元素的键合。这些化合物旨在提供主原子和金属之间的协同相互作用。这使化合物能够将不同的组汇总在一起，并在它们之间做出反应。该项目将开发系统，使反应性化学片段附在廉价且易于丰富的基板上，以在该散装和精细化学领域的应用中提供具有应用的产品。这种方法还试图用催化中的地球丰富的金属代替昂贵的稀有金属。该项目将为本科研究人员提供培训理由，并为与化学合成和X射线晶体学有关的主题提供扩展的外展活动。该项目旨在通过探索金属 - 核酸单键和多个键合成相关的基因元素和反应性nInerener nitreens nitrementrementer，旨在开发后期金属/主组互动的化学。初步发现表明，这些“电子沮丧”的链接可以实现双站点催化，从而使两个位点（金属和主元素）与不同的底物相互作用以将它们结合在一起，但是尚未证明这种策略的一般性。这种方法可以避免许多催化剂中存在的中毒问题，还提供了一种独特的方法，可以在小组转移催化剂中使用诸如铁，钴和镍等地球金属。该奖项反映了NSF的法定任务，并被认为是通过使用基金会的知识和更广泛影响的评估来审查Criteria的评估来通过评估来获得的支持。