Collaborative Research: Developmental links between teeth and faces

合作研究：牙齿和面部之间的发育联系

• 批准号: 2235657
• 负责人: Tim Smith
• 金额: $ 13.32万
• 依托单位: Slippery Rock University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2235657&HistoricalAwards=false
• 关键词: Collaborative; Research; Developmental; links; between

Faces transform from birth to adulthood. Growing and erupting teeth are among the most transformative drivers of changes in facial appearance, promoting bone formation and influencing overall jaw growth. Prior research has focused on the eruption of ‘baby teeth’, or deciduous teeth, and subsequent permanent teeth. However, the period near or at birth, when many teeth are not yet fully developed, has rarely been studied. This study investigates the role(s) of teeth in facial development during early critical periods, and results inform a better understanding regarding how different parts of anatomy can influence the appearance of others, as well as the whole organism. The project generates 3D models, a website and other resources for K-12 students and provides training and professional development to one postdoctoral scholar and multiple graduate and undergraduate students. This study investigates the underpinnings of functional matrix theory, which posits that bones that border soft tissue structures and other organs such as teeth, directly cause transformations of bone morphology. The principal investigators use the two sides of lower jaw to study cellular and tissue-level event in tooth and jaw formation, which are then mirrored on three-dimensional reconstructions of the opposite side of the jaw. The three-dimensional reconstructions are accomplished using micro computed tomographic (µCT) scanning to detect bone, following by a second scan after soaking half of the jaw in iodine, after which unmineralized tooth germs are easily detectable using µCT. Amira software are used to generate three-dimensional views that denote critical cellular and tissue-level mechanisms (i.e., cell signals for bone deposition and resorption, and bone cell maturation). µCT will also be used for morphometric analyses. Ultimately, by investigating how developing teeth compete for space within a growing face, results are relevant for interpreting variation in modern and past anatomy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

面孔从出生到成年。生长和爆发的牙齿是面部外观变化最具变革性的驱动因素之一，促进骨形成并影响整体下颌生长。先前的研究集中在“乳牙”或“决定牙齿”以及随后的恒牙上的喷发。但是，很少研究几个牙齿尚未完全发育的时期，当时许多牙齿尚未完全发育。这项研究调查了关键早期牙齿在面部发育中的作用，结果可以更好地了解解剖学的不同部分如何影响他人的外观以及整个组织。该项目为K-12学生生成3D模型，网站和其他资源，并为一位博士后科学以及多个研究生和本科生提供培训和专业发展。这项研究调查了功能基质理论的基础，该基础的基础是骨骼骨骼软组织结构和其他器官（例如牙齿）的骨骼直接导致骨形态的转化。主要研究人员使用下颌的两个侧面研究牙齿和下颌形成中的细胞和组织水平事件，然后在颌骨另一侧的三维重建上进行反映。三维重建是使用微型计算机断层扫描（µCT）扫描来检测骨骼的，随后进行第二次扫描µCT也将用于形态计量学分析。最终，通过调查牙齿在不断增长的面孔中如何争夺空间，结果与解释现代和过去解剖结构的变化有关。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子和更广泛的影响来审查标准，通过评估来诚实地支持支持。