Collaborative Research: Developmental links between teeth and faces

合作研究：牙齿和面部之间的发育联系

• 批准号: 2235665
• 负责人: Kristen Prufrock
• 金额: $ 7.46万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2235665&HistoricalAwards=false
• 关键词: Collaborative; Research; Developmental; links; between

Faces transform from birth to adulthood. Growing and erupting teeth are among the most transformative drivers of changes in facial appearance, promoting bone formation and influencing overall jaw growth. Prior research has focused on the eruption of ‘baby teeth’, or deciduous teeth, and subsequent permanent teeth. However, the period near or at birth, when many teeth are not yet fully developed, has rarely been studied. This study investigates the role(s) of teeth in facial development during early critical periods, and results inform a better understanding regarding how different parts of anatomy can influence the appearance of others, as well as the whole organism. The project generates 3D models, a website and other resources for K-12 students and provides training and professional development to one postdoctoral scholar and multiple graduate and undergraduate students. This study investigates the underpinnings of functional matrix theory, which posits that bones that border soft tissue structures and other organs such as teeth, directly cause transformations of bone morphology. The principal investigators use the two sides of lower jaw to study cellular and tissue-level event in tooth and jaw formation, which are then mirrored on three-dimensional reconstructions of the opposite side of the jaw. The three-dimensional reconstructions are accomplished using micro computed tomographic (µCT) scanning to detect bone, following by a second scan after soaking half of the jaw in iodine, after which unmineralized tooth germs are easily detectable using µCT. Amira software are used to generate three-dimensional views that denote critical cellular and tissue-level mechanisms (i.e., cell signals for bone deposition and resorption, and bone cell maturation). µCT will also be used for morphometric analyses. Ultimately, by investigating how developing teeth compete for space within a growing face, results are relevant for interpreting variation in modern and past anatomy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

从出生到成年，牙齿的生长和萌出是面部外观变化最具变革性的驱动因素之一，促进骨骼形成并影响整个颌骨的生长。然而，在出生前或出生时许多牙齿尚未完全发育的时期很少被研究，这项研究调查了早期关键时期牙齿在面部发育中的作用，并且结果提供了更好的信息。了解解剖学的不同部分如何该项目为 K-12 学生生成 3D 模型、网站和其他资源，并为一名博士后学者和多名研究生和本科生提供培训和专业发展。功能矩阵理论的基础，该理论认为，与软组织结构和其他器官（例如牙齿）接壤的骨骼直接导致骨骼形态的转变。主要研究人员利用下颌的两侧来研究牙齿中的细胞和组织水平事件。和下颌形成，然后是三维重建是通过微计算机断层扫描 (μCT) 扫描来检测骨骼，然后将一半下颌浸泡在碘中进行第二次扫描，然后进行未矿化。使用 µCT 可轻松检测牙菌，Amira 软件可生成表示关键细胞和组织水平机制（即骨沉积和吸收以及骨细胞成熟的细胞信号）的三维视图。 µCT 还将用于形态测量分析，通过研究发育中的牙齿如何在生长中的面部竞争空间，其结果与解释现代和过去解剖学的变化相关。该奖项是 NSF 的法定使命，并被认为值得通过评估支持。利用基金会的智力优势和更广泛的影响审查标准。