Collaborative Research: Developmental origins of emotional and epigenetic resilience among children

合作研究：儿童情绪和表观遗传复原力的发展起源

• 批准号: 2316775
• 负责人: Kimberly D'Anna-Hernandez
• 金额: $ 10.33万
• 依托单位: Marquette University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316775&HistoricalAwards=false
• 关键词: Collaborative; Research; Developmental; origins; emotional

This project aims to understand disparities in emotional resilience and mental health among mothers and their children who face a high burden of psychological, social, and cultural stress. The research employs biocultural and developmental frameworks to advance fundamental knowledge about how various stress and resilience factors in mothers can shape the stress biology profile of their children, through study of hormonal and molecular changes measured in children’s saliva. The results of the project can contribute to efforts to improve prevention and interventions to reduce disparities in psychological well-being. The project broadens participation of under-represented groups in STEM through mentoring and training of graduate and undergraduate students and community members. Results are shared in both academic and community outlets, supporting public science education and engagement.This study explores various biological pathways through which maternal sociocultural and emotional protective factors and stressors can alter the developing stress biology of a child. The project leverages existing data from a previously NSF-funded birth cohort of children to examine stress and resilience factors in relation to cortisol reactivity to stress tasks and changes in DNA methylation at stress-related genes at two points in childhood (6 months and 3-5 years). Results address the relative importance of early prenatal versus later postnatal exposures, the earliest timing at which stress biology may first be altered in humans, and whether altered stress reactivity signifies a trade-off that ultimately places children at higher risk for emotional or behavioral problems or impaired cognition.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在了解面对心理，社会和文化压力高度燃烧的母亲及其子女的情感韧性和心理健康的分布。研究员工生物文化和发展框架通过研究儿童唾液中测量的激素和分子变化，可以促进母亲中各种压力和弹性因素如何影响孩子的压力生物学特征的基本知识。该项目的结果可以有助于改善预防和干预措施，以减少心理健康的分布。通过研究生和本科生和社区成员的心理和培训，该项目扩大了代表性不足的群体在STEM中的参与。结果在学术和社区渠道中都分享，支持公共科学教育和参与。这项研究探讨了各种生物学途径，物质社会文化和情感保护因素和压力源可以改变儿童的发展压力生物学。该项目利用了先前由NSF资助的儿童出生队列的现有数据来检查与压力任务的皮质醇反应性有关的压力和弹性因素，以及在儿童期（6个月零3-5岁）下，在压力相关的基因上，在压力相关的基因下DNA甲基化的变化。结果解决了早期产前和晚期暴露的相对重要性，最早可能会改变压力生物学的最早时机，以及人类的压力反应性改变是否意味着使儿童最终使儿童处于情感或行为问题或行为问题的风险更高的风险或障碍的认知方面，这些奖项均表现出了NSF的智力依据，这是NSF的智力统计范围，这是由智力的统治措施，其智力是由智力的传教范围来影响。 标准。