Interrogating the Impact of Biocompatible Ionic Liquids on the Nanoaggregation of Linear-dendritic Block Copolymers

探讨生物相容性离子液体对线性树枝状嵌段共聚物纳米聚集的影响

• 批准号: 2204193
• 负责人: Eden Tanner
• 金额: $ 45万
• 依托单位: University of Mississippi
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2204193&HistoricalAwards=false
• 关键词: Interrogating; Impact; Biocompatible; Ionic; Liquids

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR), Dr. Eden E. L. Tanner of the University of Mississippi will study a novel class of polymers that consist of a linear hydrophobic section connected to a highly branched hydrophilic block. This distinct structural configuration bestows interesting properties on the polymer that can potentially be exploited for use as in drug delivery or related molecular transport applications. The Tanner Lab aims to gain a better understanding of the properties of this class of polymers, in particular the nature and strength of interactions that control the self-assembly of the polymers into uniform nano-size aggregates. The fundamental physical chemistry and polymer chemistry knowledge to be gained from this research may provide guiding principles for the rational design of polymers for biomedical or pharmaceutical applications. Dr. Tanner strives to recruit and retain Black and African-American scholars, aiming to improve STEM (science, technology, engineering and mathematics) participation among underrepresented minority students in Mississippi. In addition to providing interdisciplinary research training opportunities for students at the University of Mississippi, the Tanner Lab will host students from regional HBCUs over the summer. The Tanner Lab will interrogate the non-covalent interactions of linear-dendritic block copolymers (LDBCs) with biocompatible ionic liquids (BILs) and explore using BILs to help control LDBC self-assembly into monodisperse nanostructures. Biocompatible ionic liquids (BILs) are comprised of biocompatible bulky cations and anions and are liquids at room temperature. To understand the role that BILs play in the nano-assembly of LDBCs, Dr. Tanner and her team will investigate the nature and strength of interactions between the LDBCs and the BILs, both in pure BILs and in the presence of water, post-aggregation. They will analyze the BIL/LDBC nano-aggregates with a battery of physical and chemical techniques to gain insight on their nanoscopic composition. In addition, they will measure the thermodynamics and kinetics of degradation of the aggregates and the LDBCs themselves and quantify the impact of BILs, with the aim of relating degradation profiles to the strength of interactions between the LDBCs and BILs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系高分子、超分子和纳米化学项目以及刺激竞争研究既定项目 (EPSCoR) 的支持下，密西西比大学的 Eden E. L. Tanner 博士将研究一类新型聚合物，该聚合物由线性聚合物组成疏水部分连接到高度支化的亲水嵌段。 这种独特的结构配置赋予聚合物有趣的特性，可用于药物输送或相关分子运输应用。 坦纳实验室的目标是更好地了解此类聚合物的特性，特别是控制聚合物自组装成均匀纳米尺寸聚集体的相互作用的性质和强度。 从这项研究中获得的基本物理化学和聚合物化学知识可以为生物医学或制药应用的聚合物的合理设计提供指导原则。 坦纳博士致力于招募和留住黑人和非裔美国学者，旨在提高密西西比州代表性不足的少数族裔学生对 STEM（科学、技术、工程和数学）的参与度。除了为密西西比大学的学生提供跨学科研究培训机会外，坦纳实验室还将在夏季接待来自地区 HBCU 的学生。 Tanner 实验室将探讨线性树枝状嵌段共聚物 (LDBC) 与生物相容性离子液体 (BIL) 的非共价相互作用，并探索使用 BIL 来帮助控制 LDBC 自组装成单分散纳米结构。 生物相容性离子液体 (BIL) 由生物相容性大体积阳离子和阴离子组成，在室温下为液体。 为了了解 BIL 在 LDBC 纳米组装中发挥的作用，Tanner 博士和她的团队将研究 LDBC 和 BIL 之间相互作用的性质和强度，无论是在纯 BIL 中还是在有水存在的情况下，聚集后。 他们将使用一系列物理和化学技术来分析 BIL/LDBC 纳米聚集体，以深入了解其纳米级成分。此外，他们还将测量聚集体和 LDBC 本身降解的热力学和动力学，并量化 BIL 的影响，目的是将降解曲线与 LDBC 和 BIL 之间的相互作用强度联系起来。该奖项反映了 NSF 的法定使命通过使用基金会的智力优点和更广泛的影响审查标准进行评估，并被认为值得支持。

项目成果

Good's buffer based highly biocompatible ionic liquid modified PLGA nanoparticles for the selective uptake in cancer cells

Goods 缓冲液基于高度生物相容性离子液体修饰的 PLGA 纳米颗粒，用于癌细胞的选择性摄取

• DOI: 10.1039/d3qm00787a
• 发表时间: 2023
• 期刊: Materials Chemistry Frontiers
• 影响因子: 7
• 作者: Singh, Gagandeep;Dasanayake, Gaya S.;Chism, Claylee M.;Vashisth, Priyavrat;Kaur, Amandeep;Misra, Sandeep Kumar;Sharp, Joshua S.;Tanner, Eden E.
• 通讯作者: Tanner, Eden E.