I-Corps: Development of a Periodontal Ultrasound/Photoacoustic Imaging Device

I-Corps：牙周超声/光声成像设备的开发

• 批准号: 2129540
• 负责人: Jesse Jokerst
• 金额: $ 5万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2129540&HistoricalAwards=false
• 关键词: Corps; Development; Periodontal; Ultrasound; Photoacoustic

The broader impact/commercial potential of this I-Corps project may lead to an accurate and early detection of periodontal disease to reduce the pain and cost of dental care. Periodontal disease is common and often results in dental pain, tooth loss, reduced quality of life, and even systemic effects like cardiovascular disease. The current methods for periodontal evaluation use manual probing and visual inspection. These methods are often inaccurate and have poor reproducibility, as well as being time consuming and sometimes painful. While X-ray imaging captures detailed information about intra-oral hard tissues, more detailed information about soft tissue is missed. There is an essential unmet need for non-invasive imaging to assess dental health. This project will improve periodontal evaluation and diagnostics, treatment planning, and therapy monitoring. It may also make dental exams less painful for patients and more accurate for dentists.This I-Corps project develops a novel non-invasive periodontal imaging device that provides key information for periodontitis diagnosis. Dual modality ultrasound and photoacoustic imaging can be used as a superior alternative to the current standard of care for periodontal evaluation. This approach combines the resolution of ultrasound with the contrast and spectral behavior of optics. Photoacoustic imaging of the gingiva can detail the contours of the entire pocket with markedly less variability than conventional probing. This modality offers a perspective for early diagnosis of inflammation which is inaccessible by direct visual clinical assessment. In addition, ultrasound imaging can quantify gingival thickness which in turn, determines the final aesthetic treatment outcome. Current clinical attachment loss is visually measured based on cementoenamel junction (CEJ) location and it is only visible if gingival margin has already recessed due to disease. In contrast, the ultrasound approach can image anatomical landmarks including CEJ and gingival margin to quantify attachment loss. The successful demonstration of the proposed project may lead to an accurate diagnosis of gum disease in the early stage of gingivitis that reduces the risk of advanced periodontitis and tooth loss.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力可能会导致对牙周疾病的准确和早期发现，以减轻牙齿护理的疼痛和成本。牙周病很常见，通常会导致牙齿疼痛，牙齿脱落，生活质量降低，甚至是心血管疾病（例如心血管疾病）。当前用于牙周评估的方法使用手动探测和视觉检查。这些方法通常是不准确的，可重复性差，而且耗时，有时甚至很痛苦。 X射线成像捕获有关口腔内硬组织的详细信息，但遗漏了有关软组织的更详细信息。对于评估牙齿健康的非侵入成像是必需的。该项目将改善牙周评估和诊断，治疗计划和治疗监测。这也可能会使牙科检查对患者的疼痛减轻，对牙医的痛苦更加准确。此I-Corps项目开发了一种新型的非侵入性牙周成像装置，为牙周炎诊断提供关键信息。双重模态超声和光声成像可以用作当前护理标准进行牙周评估的替代方法。这种方法将超声的分辨率与光学的对比度和光谱行为结合在一起。牙龈的光声成像可以详细介绍整个口袋的轮廓，其变异性明显较小，而不是常规探测。这种方式为早期诊断炎症提供了一种观点，这是直接视觉临床评估无法访问的。另外，超声成像可以量化牙龈厚度，这反过来决定了最终的美学处理结果。当前的临床附着损失是根据cementoenamel Junction（CEJ）位置进行视觉测量的，只有在由于疾病引起的牙龈边缘已经凹陷时才可见。相比之下，超声方法可以对包括CEJ和牙龈边缘在内的解剖学地标成像，以量化附着损失。拟议项目的成功证明可能会导致牙龈炎早期对牙龈疾病的准确诊断，从而降低了晚期牙周炎和牙齿脱落的风险。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来通过评估来支持的。