RAPID: Collaborative Research: Development of Biocidal Nanofiber Air Filters for Reusable Personal Protective Equipment during Outbreaks of Viral Pathogens

RAPID：合作研究：开发用于病毒病原体爆发期间可重复使用的个人防护设备的杀菌纳米纤维空气过滤器

• 批准号: 2030532
• 负责人: David Cwiertny
• 金额: $ 10万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2030532&HistoricalAwards=false
• 关键词: RAPID; Collaborative; Research; Development; Biocidal

The COVID-19 pandemic has highlighted a critical need for reliable PPE for medical professionals and essential workers. This project aims to fabricate self-sterilizing personal protective equipment (PPE) material. The material will be made using electrospinning, which produces small-diameter fibers. The fibrous material will be treated with two types of biocidal agents to destroy pathogens such as viruses. These materials are expected to be transformative because they offer the potential for extended use and/or reuse of PPE. This will aid in both reducing PPE shortages in times of increased use and contribute to reduced waste. The investigators have identified hospital and industrial partners for this project. Additionally, future applications of these materials may include filtration systems for hospitals, on airplanes, and in homes and buildings, and to protect those working in agriculture.This proposal aims to produce biocidal filtration materials by electrospinning and adding novel biocide and antimicrobial treatments (tetrabutyl ammonium bromide (TBAB) and silver (Ag) nanoparticles) to produce PPE that captures and neutralizes viral pathogens. The investigators hypothesize that these novel antimicrobial composites will exhibit synergistic performance for virus inactivation by coupling physical and (bio)chemical removal mechanisms. To test this hypothesis, filter materials of varying fiber diameters will be electrospun from polystyrene and poly(vinylidene fluoride), and their filtrations performance will be evaluated using various sized polystyrene beads. The outcome of the project will be fundamental understanding of the synergistic effects of surfactant biocide (TBAB), antimicrobial silver, and easy-to-synthesize, electrospun materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

COVID-19大流行强调了对医疗专业人员和基本工人的可靠PPE的迫切需求。 该项目旨在制造自杀的个人防护设备（PPE）材料。该材料将使用产生小直径纤维的静电纺丝制成。纤维材料将用两种类型的杀菌剂处理，以破坏病毒等病原体。预计这些材料将具有变革性，因为它们为PPE的扩展使用和/或重复使用提供了潜力。这将有助于减少使用时间增加PPE短缺并导致浪费减少。调查人员已经确定了该项目的医院和工业伙伴。此外，这些材料的未来应用可能包括用于医院，飞机以及在家庭和建筑物中的过滤系统，并保护在农业中工作的人。该提案旨在通过静电纺丝和添加新型的生物剂和抗生素治疗（Tetrabutylymmonium bromyide captrations and Premmonium bromyide captrations and the ammony bromyide captor）（TBERAB）（TBERAB）（TBE）（TBER）（TBER）（TBER）（TBE）（TBER）（TBER）（TBER）（TBE）（TBER）（TBE）并中和病毒病原体。研究人员假设这些新型的抗菌复合材料将通过耦合物理和（BIO）化学去除机制表现出与病毒失活的协同性能。为了检验这一假设，纤维直径的过滤材料将是来自聚苯乙烯和聚（乙烯基氟化物）的静电传播，并使用各种大小的聚苯乙烯珠子评估其过滤性能。该项目的结果将是对表面活性剂杀菌剂（TBAB），抗微生物银和易于合成材料的协同作用的基本理解。该奖项反映了NSF的法定任务，并通过基金会的知识优点和广泛的影响来评估NSF的法定任务，并被认为是值得的支持。