MRI: Acquisition of a Liquid Chromatograph-High Resolution Mass Spectrometer to Characterize Organic Molecules of Environmental and Health Significance

MRI：获取液相色谱-高分辨率质谱仪来表征具有环境和健康意义的有机分子

• 批准号: 2018497
• 负责人: Teng Zeng
• 金额: $ 52.93万
• 依托单位: Syracuse University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018497&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatograph; Resolution

Naturally occurring and synthetic organic molecules play multifaceted roles in the ecosystem and human health. Comprehensive characterization of these organic molecules help advance our scientific understanding of various environmental and health challenges that impact society. This project supports the acquisition of a state-of-the-art liquid chromatograph-high resolution mass spectrometer (LC-HRMS) at Syracuse University (SU). This instrument will enhance research and training on the measurement of organic molecules in diverse samples and enable SU investigators and researchers in central New York to tackle multidisciplinary research questions at the interface of environment and health. This instrument will also strengthen SU’s curriculum and research training programs and broaden participation of students from underrepresented groups in scientific inquiries to foster diversity and inclusion in collaborative research and creative work at SU.Acquisition of a liquid chromatograph-high resolution mass spectrometer (LC-HRMS) will bring to Syracuse University (SU) a next-generation analytical tool to support a broad array of mass spectrometry applications ranging from contaminant screening and molecular fingerprinting to structural and quantitative proteomics. This instrument will fill a crucial gap in organic analytical facilities at SU and accelerate the pace of many ongoing and planned research projects in priority areas of national interest, such as water quality and treatment, biogeochemistry, indoor environmental quality, chemical biology, and bioinspired materials. This instrument will present new opportunities for SU faculty and students to develop novel screening and discovery workflows and to engage in new interdisciplinary collaborations with researchers spanning multiple disciplines and multiple institutions from central New York and beyond. This instrument will also expose SU students to cutting-edge mass spectrometry methods via new active-learning course modules and research training programs and equip them with analytical skills and scientific thinking needed to further their education. The long-term vision for operating this instrument as a shared user facility is to pursue leading-edge research and enhance SU’s core education mission by providing new analytical capabilities and technical expertise to SU and regional communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

天然发生和合成有机分子在生态系统和人类健康中扮演多方面的角色。这些有机分子的全面表征有助于提高我们对影响社会的各种环境和健康挑战的科学理解。该项目支持锡拉丘兹大学（SU）的最先进的液态色谱高分辨率质谱仪（LC-HRMS）。该工具将增强有关多样性样本中有机分子测量的研究和培训，并使纽约中部的SU研究人员和研究人员能够在环境和健康界面上解决多学科研究问题。该乐器还将加强SU的课程和研究培训计划，并扩大代表性不足的小组的学生参与科学探究，以促进多样性和纳入协作研究和SU的创造性工作。液态色谱分辨率高分辨率高分辨率高度光谱仪（LC-HRMS）将带来下一步的SUPRACESS（SU）范围的范围（SU），以弥补Supertions（SU）范围的范围，以弥补范围的工具，以弥补范围的工具，以弥补范围的工具，以弥补范围的工具，以范围的范围构建了范围的工具分析，并将其范围范围的分析范围造成的分析范围，并将其分析范围的分析分析范围，并将其分析范围。污染物筛选和分子指纹识别结构和定量蛋白质组学。该乐器将填补SU的有机分析设施的重要空白，并加速许多正在进行的和计划的研究项目的优先领域，例如水质和治疗，生物地球化学，室内环境质量，化学生物学和生物启发的材料。该乐器将为SU教职员工提供新的机会，以开发新颖的筛查和发现工作流程，并与跨越纽约中部及其他地区的多个学科和多个乐器的研究人员进行新的跨学科合作。该乐器还将通过新的主动学习课程模块和研究培训计划使SU学生接触到尖端的质谱法，并为他们提供分析技能和科学思维，以进一步进一步教育。作为共享用户设施运行该工具的长期愿景是通过提供新的分析能力和技术专业知识来进行SU和区域社区的新核心教育任务。该奖项反映了NSF的法定任务，并且我们是否通过使用该基金会的知识分子和更广泛的影响来评估Criteria来评估我们的支持。