Secondary Amine-Containing Organic Micropollutants as Precursors of Previously Uncharacterized N-Nitrosamines in Wastewater

含有仲胺的有机微污染物是废水中先前未表征的 N-亚硝胺的前体

• 批准号: 1927930
• 负责人: Teng Zeng
• 金额: $ 32.99万
• 依托单位: Syracuse University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1927930&HistoricalAwards=false
• 关键词: Secondary; Amine; Containing; Organic; Micropollutants

Freshwater scarcity is a major challenge both nationally and globally. Many municipalities are considering wastewater reuse as a viable solution to augmenting water supplies to address this issue. One major concern about implementing wastewater reuse stems from the potential public health risks caused by exposure to wastewater-derived pollutants such as N-nitrosamines. Despite this recognition, there remain gaps in our knowledge regarding the formation and prevalence of these compounds. This project will address this gap by investigating the fate and reactivity of precursors that serve as the source of N-nitrosamines in wastewater. Successful completion of this research will benefit water utilities in their ability to monitor N-nitrosamines and assess treatment efficiency of advanced treatment technologies. Regulatory agencies may also find project results useful to assess the risk of N-nitrosamines. This project will provide valuable research training opportunities for underrepresented high school and college students to broaden opportunity and diversify the Nation's STEM workforce. The outreach program will promote direct knowledge transfer to the scientific stakeholder communities, while improving the scientific literacy of the Nation.N-Nitrosamines are contaminants of potential public health concern for planned and de facto reuse of municipal wastewater effluent. To date, research on N-nitrosamines has focused primarily on N-nitrosodimethylamine (NDMA) and a few other aliphatic or cyclic species. Relatively limited knowledge exists regarding the sources, identities, fate, and risks of uncharacterized N-nitrosamine species. The overall goal of this research project is to address this knowledge gap by 1) examining the yields and formation mechanisms of N-nitroso derivatives upon chloramination of secondary amine-containing pharmaceuticals and pesticides; 2) establishing the relative importance of secondary amine-containing micropollutants as precursors of uncharacterized N-nitrosamines in full-scale wastewater treatment and reuse facilities; and 3) evaluating the impacts of photo- and biotransformation processes on secondary amine-containing micropollutants in wastewater-impacted surface waters. The approach will include both high resolution mass spectrometry and chemiluminescence assays of field samples and bench-scale testing to accomplish the proposed research tasks. An outreach and education plan will seek to broaden participation of underrepresented high school and undergraduate students in environmental research; incorporate research methodologies and outcomes into the environmental curriculum at Syracuse University; and disseminate research results to the broader scientific community, stakeholders, and lay public to improve monitoring and mitigation strategies for N-nitrosamines and their precursors in wastewater.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

淡水稀缺是全国和全球的主要挑战。许多市政当局都将废水重用是增加水供应以解决此问题的可行解决方案。对实施废水再利用的一个主要关注点是由于暴露于废水衍生的污染物（如N-硝基胺）所带来的公共卫生风险。尽管认识到这种认可，但我们关于这些化合物的形成和流行率的知识仍然存在差距。该项目将通过研究作为废水中N-硝基胺的来源的前体的命运和反应性来解决这一差距。这项研究的成功完成将使水公用事业受益于其监测N-亚硝基胺的能力并评估高级治疗技术的治疗效率。监管机构还可能发现项目结果有助于评估N-亚硝基胺的风险。该项目将为代表性不足的高中和大学生提供宝贵的研究培训机会，以扩大机会并使国家的STEM劳动力多样化。外展计划将促进直接的知识转移到科学利益相关者社区，同时提高国家的科学素养。N-硝基胺是潜在的公共卫生关注的污染物，即计划和事实上重复使用市政废水废水。迄今为止，对N-亚硝基胺的研究主要集中在N-硝基二甲胺（NDMA）和其他一些脂肪族或周期性物种上。关于未表征的N-硝基胺物种的来源，身份，命运和风险的知识相对有限。该研究项目的总体目的是通过1）研究含二胺的药物和农药的氯化剂时，研究N-硝基衍生物的产量和形成机制； 2）确定含二胺微污染物作为在全尺度废水处理和再利用设施中未表征的N-硝基胺的前体的相对重要性； 3）评估光和生物转化过程对废水冲击的地表水中含次胺微污染物的影响。该方法将包括高分辨率质谱法和现场样品的化学发光测定和台式测试，以完成所提出的研究任务。推广和教育计划将寻求扩大代表性不足的高中和本科生参与环境研究的参与；将研究方法和结果纳入锡拉丘兹大学的环境课程；并将研究结果传播给更广泛的科学界，利益相关者和公众公开场所，以改善对N-亚硝基胺及其在废水中的前体的监测和缓解策略。该奖项反映了NSF的法定任务，并认为通过基金会的知识分子和更广泛的影响，可以通过评估来审查CRITERIA，并认为通过评估的支持值得。