Technician Training in CRISPR-based Gene Editing

基于 CRISPR 的基因编辑技术人员培训

• 批准号: 2000696
• 负责人: John McDowell
• 金额: $ 57.43万
• 依托单位: Delaware Technical & Community College Stanton-Newark Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2000696&HistoricalAwards=false
• 关键词: Technician; Training; CRISPR; based; Gene

CRISPR-based gene editing is revolutionizing biological research as a mechanism to efficiently and precisely modify the genome of almost any organism. As a result of the wide incorporation of CRISPER-based technologies in genetic engineering, there is a need for a biotechnology workforce that is trained in its use. Community colleges are adept at meeting rapidly changing workforce needs such as this. To this end, Delaware Technical Community College proposes to develop and incorporate CRISPR-based gene editing training into its biotechnology curriculum. This work will be done in collaboration with the Gene Editing Institute at ChristianaCare, a Delaware-based healthcare organization. The project also aims to provide workshops to train community college faculty across the nation in CRISPR-based gene editing techniques. The trained faculty can in turn educate large numbers of students about this gene editing technique, to better prepare students for the current biotechnology workforce. This partnership combines the content expertise of staff at the Gene Editing Institute with that of faculty at Delaware Technical Community College to develop and implement a high impact CRISPR-based gene editing curriculum and to offer training workshops for faculty. The project includes engagement with industry partners and national experts in bioethics. The professional development workshops will enable participants to broaden biotechnology instruction related to CRISPR use, as well related ethical issues. Through these activities, the project expects to serve nearly 100 bioscience students at Delaware Technical Community College and 90 community college faculty. The intention is to help students gain the knowledge and skills needed to contribute to a rapidly expanding field with a wide range of applications. The specific aims of the project are to: (1) continue to update and provide effective training in state-of-the-art gene editing techniques to prepare students in a two-year biotechnology program to enter bioscience careers or further education; (2) disseminate an advanced, current curriculum and model high impact teaching practices to community college instructors through three and five day gene editing workshops. The employability skills of graduates will be strengthened and broadened with the use of classroom activities that involve analysis and interpretation of bioinformatic data, technical oral presentations, understanding and evaluation of scientific literature, and group work as examples. As a result of these efforts, the project team expects to contribute to the national need for technicians who are skilled in gene editing technologies. This project is funded by the Advanced Technological Education program that focuses on the education of technicians for the advanced-technology fields that drive the nation's economy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

基于CRISPR的基因编辑正在将生物学研究革新，以此作为一种有效，精确地修改几乎所有生物体的基因组的机制。 由于在基因工程中广泛纳入了基于清晰的技术，因此需要对其使用培训的生物技术劳动力。社区学院擅长满足诸如此类的快速变化的劳动力需求。 为此，特拉华州技术社区学院建议开发并纳入基于CRISPR的基因编辑培训培训纳入其生物技术课程中。这项工作将与位于特拉华州的医疗组织ChristianAcare的基因编辑研究所合作完成。该项目还旨在提供讲习班，以基于CRISPR的基因编辑技术来培训全国各地的社区大学教师。训练有素的教职员工可以依次教育大量学生有关这种基因编辑技术的知识，以更好地为学生做好当前生物技术劳动力的准备。该合作伙伴关系将基因编辑研究所员工的内容专业知识与特拉华技术社区学院的教师的内容专业知识相结合，以开发和实施高影响力的基于CRISPR的基因编辑课程，并为教师提供培训讲习班。该项目包括与行业合作伙伴和国家生物伦理专家的互动。专业发展研讨会将使参与者能够扩大与CRISPR使用以及相关的道德问题相关的生物技术教学。 通过这些活动，该项目预计将为特拉华州技术社区学院和90个社区学院教职员工提供近100名生物科学学生。目的是帮助学生获得通过广泛应用的快速扩展领域贡献所需的知识和技能。该项目的具体目的是：（1）继续在最先进的基因编辑技术中进行更新并提供有效的培训，以使学生在为期两年的生物技术计划中为学生做好准备，以进入生物科学职业或进一步的教育； （2）通过三天和五天的基因编辑研讨会向社区大学讲师传播高级，当前的课程和模型高影响力教学实践。毕业生的就业能力将通过使用课堂活动来加强和扩展，这些活动涉及分析和解释生物信息学数据，技术口头介绍，对科学文献的理解和评估以及小组工作作为例子。由于这些努力，项目团队希望为国家熟练的基因编辑技术技术人员的国家需求做出贡献。该项目由先进的技术教育计划资助，该计划的重点是推动国家经济的高级技术领域的技术人员的教育。该奖项反映了NSF的法定任务，并被认为是通过基金会的智力优点和更广泛影响的审查标准通过评估来通过评估来支持的。