Genomics of Diseases in Wildlife Workshop; June 2-9, 2019; May/June, 2020; Fort Collins, CO

野生动物疾病基因组学研讨会；

• 批准号: 1926958
• 负责人: Sue VandeWoude
• 金额: $ 2万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1926958&HistoricalAwards=false
• 关键词: Genomics; Diseases; Wildlife; Workshop; June

Wildlife populations can be drastically affected by the outbreak and transmission of infectious diseases. Examples of this include white nose syndrome which is devastating bat populations in the US, and Chytrid fungus outbreaks that have caused declines in frog populations worldwide. Some diseases of wildlife, for example, Rabies, Ebola, and West Nike Virus, can cause outbreaks of disease in people, while other infections of wildlife, such as Brucellosis and African Swine Fever, can be fatal to domestic animals and livestock. Extraordinary new tools greatly improve our ability to detect infection and understand why it sometimes is devastating and sometimes not. While these new technologies make this an exciting time for new discoveries and understanding that will improve wildlife disease management, many researchers would benefit from training in their use. To address this need, we offer hands-on training with real-world data through an intensive workshop "Genomics of Disease in Wildlife" (GDW). The first two workshops offered in 2017 and 2018 were very successful and provided training for nearly 50 graduate students, post-doctoral fellows, and faculty in Next Generation DNA Sequencing analysis to use in projects about wildlife diseases. Going forward, this project will provide scholarships to 12-14 graduate students or fellows (US citizens) with financial need to attend workshops in 2019 and 2020. We will preferentially use these funds to enhance diverse or underrepresented minority participation and have been successful in recruiting women and diverse attendees to maximize training impacts. This financial assistance will also facilitate building a cohesive, effective scientific community making breakthroughs in control of infectious wildlife diseases. For example, we have recently published a manuscript helping the scientific community identify critical next challenges, and the GDW workshop alumni are also involved in a listserv to promote communications among a growing number of researchers with interest and expertise in GDW problems. Recent technological advances in genomic sciences, and increasingly affordable Next Generation Sequencing (NGS) assay costs, have coalesced to result in powerful tools to monitor, detect, and reconstruct the past, present, and future role of pathogens impacting wildlife populations. Wildlife researchers are thus uniquely positioned to merge ecological, biological, and evolutionary studies with such genomic technologies to exploit unprecedented "Big Data" tools in disease research; however, most researchers lack the training and expertise required to use these computationally intensive methodologies. Previous workshops have consisted of lectures, daily computer labs, and analysis of real-world NGS data. Previous workshops have provided comprehensive training in the use of genomic tools for investigations of a broad range of interactions between wildlife host species and their pathogens, and provided unique networking opportunities among instructors, guest speakers, and participants. This project will provide support for two additional years of workshops. Funds will be awarded as scholarships for US graduate students and post-doctoral fellows interested in obtaining skills in this emerging area. This award will encourage participation by early career researchers. Participants will learn modern genomics techniques and generate powerful genomic solutions to ameliorate the local, regional, and global impact of wildlife disease.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

野生动植物种群可能会受到传染病的爆发和传播的巨大影响。其中的例子包括白鼻综合症，在美国造成了破坏性的蝙蝠种群，以及导致全球青蛙种群下降的Chytrid真菌暴发。 一些野生动植物的疾病，例如狂犬病，埃博拉病毒和西耐克病毒，可能引起人们的疾病爆发，而野生动植物的其他感染（例如布鲁克西病和非洲猪发烧）可能对家畜和牲畜致命。 非凡的新工具大大提高了我们检测感染的能力，并理解为什么有时会造成毁灭性，有时不会造成毁灭性。尽管这些新技术使这一新发现和理解将成为一种令人兴奋的时刻，这将改善野生动植物疾病的管理，但许多研究人员将受益于他们的使用培训。为了满足这一需求，我们通过密集的研讨会“野生动植物的疾病基因组”（GDW）提供实践培训。 2017年和2018年提供的前两个讲习班非常成功，并为近50名研究生，博士后研究员和下一代DNA测序分析的教师提供了培训，可用于有关野生动植物疾病的项目。展望未来，该项目将向12-14名研究生或研究员（美国公民）提供奖学金，在2019年和2020年参加研讨会。我们将优先使用这些资金来增强多样性或代表性的少数群体参与，并成功地招募妇女和多样化的与会者，以最大程度地提高培训培训影响。这种经济援助还将促进建立一个有效的，有效的科学界，从而在控制感染性野生动植物疾病方面取得突破。例如，我们最近发表了一份手稿，帮助科学界确定​​了关键的下一个挑战，而GDW研讨会校友也参与了列表服务，以促进越来越多的具有GDW问题感兴趣和专业知识的研究人员之间的沟通。 基因组科学的最新技术进步，以及越来越负担得起的下一代测序（NGS）测定成本，结合了结合，从而产生了强大的工具来监测，检测和重建影响野生动植物种群病原体的过去，现在和未来作用。因此，野生动植物的研究人员在与此类基因组技术中合并生态，生物学和进化研究的独特位置，以利用疾病研究中前所未有的“大数据”工具；但是，大多数研究人员缺乏使用这些计算密集型方法所需的培训和专业知识。以前的研讨会包括讲座，每日计算机实验室以及对现实世界NGS数据的分析。 以前的研讨会为使用基因组工具提供了全面的培训，以调查野生动植物宿主物种及其病原体之间的各种相互作用，并在讲师，演讲者和参与者之间提供了独特的网络机会。该项目将为另外两年的研讨会提供支持。资金将被授予美国研究生和有兴趣获得该新兴地区技能的博士后研究员的奖学金。该奖项将鼓励早期职业研究人员参与。 参与者将学习现代基因组学技术，并产生强大的基因组解决方案，以改善野生动植物疾病的本地，区域和全球影响。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准通过评估来获得支持的。