Mentored Research (K01) Integrative Spatial Epidemiology Study of Wildlife Rabies Spillover

指导研究（K01）野生动物狂犬病溢出的综合空间流行病学研究

• 批准号: 10591846
• 负责人: Luis E Escobar
• 金额: $ 12.64万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-27 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591846
• 关键词: Achievement; Address; Americas; Animals; Area; Biodiversity; Bioinformatics; Biology; COVID-19; Cattle; Characteristics; Chiroptera; Classification; Climate; Communicable Diseases; Data; Development; Disease; Doctor of Philosophy; Domestic Animals; Ebola; Ecology; Economics; Environmental Risk Factor; Epidemiology; Evolution; Expenditure; Exposure to; Funding; Genetic Structures; Genomics; Geographic Distribution; Geographic Factor; Geographic Locations; Geography; Goals; Habitats; Health; Human; Incidence; Individual; Industry; Infection; Institution; Knowledge; Laboratories; Latin America; Link; Livestock; Machine Learning; Mammals; Measures; Medical; Mentors; Methods; Mexico; Minnesota; Mission; Modeling; Molecular Epidemiology; Nature; Organism; Pattern; Persons; Phylogenetic Analysis; Prevention; Public Health; Rabies; Rabies virus; Recording of previous events; Report (document); Research; Research Personnel; Research Project Grants; Research Proposals; Risk; Role; Shapes; Signal Transduction; Solid; System; Temperature; Testing; Training; United States; United States National Institutes of Health; Universities; Vaccination; Virginia; Virus; Zoonoses; career; disease diagnostic; epidemiology study; genomic data; improved; innovation; insight; machine learning model; mortality; multiple datasets; novel; pathogen; pathogen spillover; post-doctoral training; prevent; previous epidemic; professor; skills; spatial epidemiology; technological innovation; tenure track; transmission process; viral transmission

SUMMARY Synopsis: This is a K01 application by Dr. Luis Escobar, researcher on zoonotic infectious diseases. Escobar’s project Integrative Spatial Epidemiology Study of Wildlife Rabies Spillover will combine spatial modeling with large epidemiological, genomic, and ecological data to investigate pathogen spillover from wildlife to humans and livestock. Candidate: PI Escobar, DVM/MSc/PhD, is a tenure-track Assistant Professor at Virginia Tech, with prior postdoctoral training at SUNY Upstate Medical University and the University of Minnesota and a strong record of scientific achievements. This application has three training objectives to strengthen Escobar’s research as an independent investigator: (1) Training in bioinformatics; (2) Integrate bioinformatics with spatial epidemiology; and (3) Gaining skills in laboratory management and research proposal development to transition to career independence. Mentors: Prof. X.J. Meng, with a solid history of NIH funding, outstanding expertise in bioinformatics, and at the applicant’s institution, will serve as Primary Mentor. Four additional mentors (Drs. Z. Tu, W. Hopkins, S. VandeWoude, A.T. Peterson) will provide complementary expertise and will assess Escobar’s progress towards career independence. Research: Emergent infectious diseases, such as Ebola, Nipah, and COVID-19, have been linked to pathogen spillover from bats to other species. A gap in knowledge exists in the fundamental ecology of pathogen spillover transmission (i.e., Where does it occur and why?), which limits understanding of previous epidemics and capacities to prevent disease emergence. This project will study pathogen spillover from bats to humans and livestock using rabies from the common vampire bat (Desmodus rotundus), a well-documented system of a virus that frequently spills from D. rotundus bats over to other species. While D. rotundus-rabies is restricted to Latin America, it is rapidly expanding towards the United States (US) for unknown reasons. The central hypothesis is that D. rotundus-rabies spillover does not occur randomly in the geography but follows specific biodiversity and habitat patterns, which can be used to predict where pathogen spillover will occur. Aim 1 will determine the role of habitat and virus lineage on rabies-spillover to humans and livestock across Latin America. Aim 2 will identify effect of biodiversity composition on rabies virus spillover transmission. Aim 3 will investigate genomic, geographic, and environmental factors shaping the spread of rabies virus. This hypothesis-driven project has conceptual and technological innovations and combines the expertise of PI Escobar and mentors to illuminate ecological drivers of rabies spillover. Findings will offer new mechanistic insights to explain and anticipate pathogen spillover. As such, this K01 application will facilitate Escobar’ s transition towards research independence and offers exciting discoveries on the ecology of spillover transmission, aligned with the NIH mission to seek fundamental knowledge about the nature of living systems to enhance human health.

概括 简介：这是人畜共患性传染病研究员Luis Escobar博士的K01应用。 Escobar的项目 野生动植物狂犬病Spilover的综合空间流行病学研究将将空间建模与大型建模相结合 流行病学，基因组和生态数据研究了从野生动植物到人类和牲畜的病原体。 候选人：DVM/MSC/PhD的Pi Escobar是弗吉尼亚理工大学的终身助理教授 在纽约州立大学医科大学和明尼苏达大学的培训和科学培训 成就。该应用程序具有三个培训目标，以加强Escobar作为独立研究者的研究： （1）生物信息学培训； （2）将生物信息学与空间流行病学相结合； （3）在实验室中获得技能 管理和研究建议的发展，要过渡到职业独立性。 导师：X.J.教授Meng，拥有NIH资金的悠久历史，生物信息学方面的出色专业知识，并在 申请人机构将担任主要导师。另外四个导师（Z. Tu博士，W。HOPKINS，S。Vandewoude， 在。 Peterson）将提供完整的专业知识，并将评估Escobar在职业独立方面的进步。 研究：新兴的传染病，例如埃博拉病毒，NIPAH和COVID-19与病原体Spilover有关 从蝙蝠到其他物种。知识的差距存在于病原体Spilover传播的基本生态学（即 它在哪里发生，为什么？），哪些限制了对先前发作的理解和预防疾病的能力 出现。该项目将使用共同 吸血鬼蝙蝠（Desmodus rotundus），这是一个有据可查的病毒系统，经常从D. rotundus蝙蝠洒到 其他物种。虽然D. rotundus-rabies仅限于拉丁美洲，但它正在迅速扩展到美国 （我们）出于未知原因。中心假设是，D。rotundus-rabies spilover不会随机发生 地理但遵循特定的生物多样性和栖息地模式，可用于预测病原体的spilover将在哪里 AIM 1将确定栖息地和病毒谱系在拉丁语中对人类和牲畜的狂犬病的作用 美国。 AIM 2将确定生物多样性组成对狂犬病病毒Spilover传播的影响。 AIM 3将调查 基因组，地理和环境因素塑造了狂犬病病毒的传播。这个假设驱动的项目有 概念和技术创新，并结合了Pi Escobar和导师的专业知识，以阐明生态 狂犬病的司机。调查结果将提供新的机械见解，以解释和预测病原体的Spilover。作为 这样的K01应用程序将有助于Escobar向研究独立性的过渡，并提供令人兴奋的发现 关于Spilover传播的生态，与NIH的使命保持一致，以寻求有关性质的基本知识 增强人类健康的生活系统。