Planning Grant: Engineering Research Center for Adaptive Small-systems for data Analytic Pain Management (ERC-ASAP)

规划资助：数据分析疼痛管理自适应小型系统工程研究中心（ERC-ASAP）

• 批准号: 1840468
• 负责人: Reza Ghodssi
• 金额: $ 10万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1840468&HistoricalAwards=false
• 关键词: Planning; Grant; Engineering; Research; Center

The Planning Grants for Engineering Research Centers competition was run as a pilot solicitation within the ERC program. Planning grants are not required as part of the full ERC competition, but intended to build capacity among teams to plan for convergent, center-scale engineering research.The National Academy of Medicine's Institute of Medicine (IOM) estimates that 116 million people in the United States are impacted by pain every year, at an annual cost to the country in the hundreds of billion dollars. Chronic pain conditions are particularly difficult to treat, since pain is a complex experience that is not the result of a single factor. The key to better understand the complexity of pain conditions is to identify the biological changes it creates. The Engineering Research Center for Adaptive Small-systems for data Analytic Pain management (ERC-ASAP) proposes to place miniaturized autonomous sensing systems in several areas of the body. This will allow simultaneous monitoring of biological activities across multiple organs, providing insight into the causes of chronic pain and its onset. This grant enables planning activities to establish the proposed Center, potentially leading to new breakthrough technologies for diagnosis and monitoring that could alter the national pain management landscape.The activities of the NSF ERC-ASAP Planning Grant will allow for the development of the management structures and multi-disciplinary team formation. Planning grant activities will also include a diverse set of stakeholder community members, necessary for effective convergent engineering practices. The center goals are to engage representatives from the main stakeholder community for constructive dialogues to identify challenges and solutions. One major outcome will be to co-develop the center mission and goals with active, continuous user community collaboration and investment. Expert-guided stakeholder engagement workshops will build and establish a strong partnership with institutional and industrial collaborators, as well as medical experts, systems engineers and data scientists, health professionals, decision and social behavior scientists, and federal regulators. In addition, a state-wide online survey and questionnaire will be conducted within the health service community to identify specific challenges, delivery, treatment options, and payer models for a device-driven engineering approach.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

工程研究中心规划补助金竞赛是作为 ERC 计划内的试点征集活动进行的。 整个 ERC 竞赛并不需要规划拨款，而是旨在培养团队之间的能力，以规划融合的、中心规模的工程研究。美国国家医学院医学研究所 (IOM) 估计，美国有 1.16 亿人各州每年都会受到痛苦的影响，每年给国家造成数千亿美元的损失。慢性疼痛特别难以治疗，因为疼痛是一种复杂的经历，不是单一因素造成的。更好地了解疼痛状况的复杂性的关键是识别它所产生的生物学变化。数据分析疼痛管理自适应小型系统工程研究中心 (ERC-ASAP) 提议在身体的多个区域放置小型化自主传感系统。这将允许同时监测多个器官的生物活动，从而深入了解慢性疼痛的原因及其发作。 这笔赠款使规划活动能够建立拟议的中心，有可能带来新的突破性诊断和监测技术，从而改变国家疼痛管理格局。 NSF ERC-ASAP 规划赠款的活动将允许开发管理结构和多学科团队的组建。规划资助活动还将包括不同的利益相关者社区成员，这是有效的融合工程实践所必需的。该中心的目标是让主要利益相关者群体的代表参与建设性对话，以确定挑战和解决方案。一项主要成果将是通过积极、持续的用户社区协作和投资来共同制定中心的使命和目标。专家指导的利益相关者参与研讨会将与机构和行业合作者以及医学专家、系统工程师和数据科学家、卫生专业人员、决策和社会行为科学家以及联邦监管机构建立牢固的伙伴关系。此外，还将在卫生服务社区内进行全州范围的在线调查和问卷调查，以确定设备驱动的工程方法的具体挑战、交付、治疗方案和付款人模型。该奖项反映了 NSF 的法定使命，并被视为值得通过使用基金会的智力优点和更广泛的影响审查标准进行评估来支持。

项目成果

Biomimetic Barbed Microneedles for Highly Robust Tissue Anchoring

用于高度坚固的组织锚定的仿生带刺微针

• DOI: 10.1109/mems46641.2020.9056127
• 发表时间: 2020-01-01
• 期刊: 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS)
• 作者: Sanwei Liu;Sangwook Chu;George E. Banis;L. Beardslee;R. Ghodssi
• 通讯作者: R. Ghodssi

Hybrid and Passive Tissue-Anchoring Mechanism for Ingestible Resident Devices

用于可摄入居民设备的混合和被动组织锚定机制

• DOI: 10.1109/jmems.2020.2999448
• 发表时间: 2020-10-01
• 期刊: Journal of Microelectromechanical Systems
• 影响因子: 2.7
• 作者: Sanwei Liu;Sangwook Chu;L. Beardslee;R. Ghodssi
• 通讯作者: R. Ghodssi

A Hybrid Biomonitoring System for Gut-Neuron Communication

用于肠道神经元通讯的混合生物监测系统

• DOI: 10.1109/jmems.2020.3000392
• 发表时间: 2020-06-23
• 期刊: Journal of Microelectromechanical Systems
• 影响因子: 2.7
• 作者: A. Chapin;Jin;Ta Ho;J. Herberholz;R. Ghodssi
• 通讯作者: R. Ghodssi

Capacitive sensing of triglyceride film reactions: a proof-of-concept demonstration for sensing in simulated duodenal contents with gastrointestinal targeting capsule system

甘油三酯薄膜反应的电容传感：利用胃肠道靶向胶囊系统对模拟十二指肠内容物进行传感的概念验证演示

• DOI: 10.1039/d0lc00133c
• 发表时间: 2020-06
• 期刊: Lab on a Chip
• 影响因子: 6.1
• 作者: Banis, George E.;Beardslee, Luke A.;Stine, Justin M.;Sathyam, Rajendra Mayavan;Ghodssi, Reza
• 通讯作者: Ghodssi, Reza

Ingestible Sensors and Sensing Systems for Minimally Invasive Diagnosis and Monitoring: The Next Frontier in Minimally Invasive Screening

用于微创诊断和监测的可摄入传感器和传感系统：微创筛查的下一个前沿

• DOI: 10.1021/acssensors.9b02263
• 发表时间: 2020-04
• 期刊: ACS Sensors
• 影响因子: 8.9
• 作者: Beardslee, Luke A.;Banis, George E.;Chu, Sangwook;Liu, Sanwei;Chapin, Ashley A.;Stine, Justin M.;Pasricha, Pankaj Jay;Ghodssi, Reza
• 通讯作者: Ghodssi, Reza