I-Corps: 6Sensing: Chip-scale Raman sensors

I-Corps：6Sensing：芯片级拉曼传感器

• 批准号: 1851293
• 负责人: Juejun Hu
• 金额: $ 5万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-11-15 至 2020-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1851293&HistoricalAwards=false
• 关键词: Corps; 6Sensing; Chip; scale; Raman

The broader impact/commercial potential of this I-Corps project is to provide on-chip optical sensors that enable faster and cheaper production of drugs and chemicals. Pharmaceutical R&D and production rely heavily on chemical analysis to provide insight into the processes at play, however analytical instruments do not follow the latest manufacturing trends towards single-use technologies and smaller batches, or even continuous production. Integrated (on-chip) photonics is an attractive sensing platform thanks to its small form factor, robustness, large multiplexing capability, and tight optical confinement that enhances light-matter interactions. This project will pioneer the large-scale use of integrated photonic sensors starting with chemical sensing, paving the way to other applications. By enabling a better understanding of the reactions at play in manufacturing processes, the proposed technology is poised to impact the pharmaceutical market and help improving public health.This I-Corps project aims to develop the first practical implementation of a microchip-scale optical spectrometer. Integrated photonic product remain scarce due to several barriers at the fabrication and packaging levels. This project will mitigate these issues to offer equivalent sensitivity and performance to large benchtop optical spectrometers in a dramatically smaller form factor. This will be realized by combining recent advances in integrated photonic component design, photonic chip architecture, and optical packaging. The proposed sensor will enable novel chemical sensing applications and help with the understanding of processes at play in areas such as cell-based manufacturing and continuous-flow chemical manufacturing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是提供芯片光学传感器，使药物和化学物质的生产更快，更便宜。药品研发和生产在很大程度上依赖化学分析来洞悉发挥作用的过程，但是分析工具并未遵循对一次性技术和较小批次甚至连续生产的最新制造趋势。综合（片上）光子学是一个有吸引力的传感平台，这要归功于其较小的外形，稳健性，大型多路复用能力和紧密的光学限制，从而增强了光 - 互动的相互作用。该项目将开创从化学传感开始的集成光子传感器的大规模使用，从而为其他应用铺平了道路。通过更好地了解制造过程中的反应，该提议的技术有望影响制药市场并有助于改善公共卫生。该I-Corps项目旨在开发对微芯片尺度光谱光谱仪的首次实践实施。由于制造和包装水平的几个障碍，集成的光子产品仍然很少。该项目将减轻这些问题，以在较小的外形尺寸中提供与大型台式光谱仪相同的灵敏度和性能。这将通过结合集成光子组件设计，光子芯片架构和光包装的最新进展来实现。拟议的传感器将实现新颖的化学传感应用，并有助于理解基于细胞的制造和连续流化学制造等领域的过程。该奖项反映了NSF的法定任务，并被认为是值得通过使用该评估的支持。基金会的智力优点和更广泛的影响评论标准。