STTR Phase I: Smartphone-based blood pressure monitoring via the oscillometric finger pressing method

STTR 第一阶段：通过示波手指按压法进行基于智能手机的血压监测

• 批准号: 1843514
• 负责人: Marc Zemel
• 金额: $ 22.5万
• 依托单位: DIGITOUCH HEALTH LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2020-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1843514&HistoricalAwards=false
• 关键词: STTR; Phase; Smartphone; based; blood

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to drive hypertension awareness and control rates around the world, through the availability of low-cost, portable blood pressure monitoring. High blood pressure (BP) is a major cardiovascular risk factor that affects up to 1 billion people worldwide. It is treatable, yet hypertension awareness and control rates are low. Ubiquitous BP monitoring technology could improve hypertension management, but existing devices require an inflatable cuff and therefore do not afford anytime, anywhere measurement of BP. The market for a portable, cuff-less blood pressure monitor is estimated in the tens of billions of dollars. Successful completion of this project via demonstration of measurement accuracy across a broad range of blood pressures will provide the company with a strong position in this large market. Ultimately, the success of this project could translate to much greater awareness and control of hypertension, helping reduce the incidence and burden of cardiovascular disease around the world.This Small Business Technology Transfer (STTR) Phase I project aims to develop a technology for cuff-less and calibration-free measurement of blood pressure via a button on a smartphone. Existing automated cuff-based monitors are bulky and do not enable anytime, anywhere measurement of BP. The 'oscillometric finger pressing method'is an emerging approach that uses the same measurement principle that is employed by most automatic cuff devices, but instead of inflating a cuff, the user presses his or her finger (and the underlying artery) against a combination of optical and pressure sensors to determine the blood pressure. The objectives of this program are to shrink the current prototype design and validate its accuracy. The proposed R&D plan includes miniaturization of the circuit components to mount them on a single board and optimization of the sensing technology and algorithm to work in a broad range of normotensive and hypertensive individuals. This work will be followed up by a clinical test of the monitor. The resulting device is expected to be small and thin enough to mount to the back of a smartphone and demonstrate clinical-grade accuracy for the measurement of blood pressure.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业技术转让 (STTR) 第一阶段项目的更广泛影响/商业潜力是通过提供低成本便携式血压监测来提高全世界的高血压意识和控制率。高血压 (BP) 是一个主要的心血管危险因素，影响着全世界多达 10 亿人。它是可以治疗的，但高血压的知晓率和控制率较低。无处不在的血压监测技术可以改善高血压管理，但现有设备需要充气袖带，因此无法随时随地测量血压。便携式无袖血压计的市场估计达数百亿美元。通过展示各种血压的测量精度，该项目的成功完成将为该公司在这个庞大的市场中占据强有力的地位。最终，该项目的成功可以提高人们对高血压的认识和控制，从而帮助减少全世界心血管疾病的发病率和负担。该小型企业技术转让（STTR）第一阶段项目旨在开发一种用于袖带的技术通过智能手机上的按钮即可进行更少且无需校准的血压测量。现有的基于袖带的自动监测仪体积庞大，无法随时随地测量血压。 “示波手指按压法”是一种新兴方法，它使用与大多数自动袖带装置相同的测量原理，但用户不是给袖带充气，而是将他或她的手指（和下面的动脉）压在以下组合上：光学和压力传感器来确定血压。该计划的目标是缩小当前的原型设计并验证其准确性。拟议的研发计划包括电路元件的小型化以将其安装在单板上，以及传感技术和算法的优化以适用于广泛的正常血压和高血压个体。这项工作之后将对显示器进行临床测试。由此产生的设备预计将足够小和薄，可以安装在智能手机背面，并展示血压测量的临床级准确性。该奖项反映了 NSF 的法定使命，并通过使用基金会的评估进行评估，认为值得支持。智力价值和更广泛的影响审查标准。