MRI: Acquisition of a Single Crystal X-Ray Diffractometer for Structure Determination and Diffuse Scattering on Small Molecules, Macromolecules, and Materials

MRI：获取单晶 X 射线衍射仪，用于小分子、大分子和材料的结构测定和漫散射

• 批准号: 1828078
• 负责人: Elizabeth Papish
• 金额: $ 33.96万
• 依托单位: University of Alabama Tuscaloosa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828078&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; Ray; MRI; Acquisition; Single; Crystal; Ray

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Elizabeth Papish from University of Alabama Tuscaloosa and colleagues Kevin Shaughnessy, Paul Rupar, Jack Dunkle and Jared Allred have acquired a dual source single crystal diffractometer equipped with a high resolution detector. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research and research training of graduate and undergraduate students in chemistry and biochemistry at this institution. Students are involved in chemical and protein research. The resource is also utilized by several neighboring primarily undergraduate institutions and historically black colleges and universities (HBCUs). The award of the diffractometer is aimed at enhancing research and education at all levels. It especially impacts the characterization of solid materials and new polymers to harness solar energy and studies of diffuse X-ray scattering to determine how local changes in structure lead to macroscopic properties. The instrumentation is also used for studies following the syntheses of monodisperse small nanomolecules and the design of catalysts for carbon dioxide reduction and cross-coupling. The diffractometer benefits studies of biological macromolecules to understand gene expression and antibiotic resistance.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。来自阿拉巴马大学Tuscaloosa大学的Elizabeth Papish教授和同事Kevin Shaughnessy，Paul Rupar，Jack Dunkle和Jared Allred收购了配备高分辨率探测器的双源单晶衍射仪。通常，X射线衍射仪可以准确，精确地测量分子的完整三维结构，包括键距离和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。这里描述的研究影响了许多领域，包括有机和无机化学，材料化学和生物化学。该工具是该机构化学和生物化学研究生和本科生的教学和研究培训的组成部分。学生参与化学和蛋白质研究。该资源还被几个邻近的本科机构和历史悠久的黑人学院（HBCUS）使用。衍射仪的奖励旨在增强各个级别的研究和教育。它尤其影响固体材料和新聚合物的表征，以利用太阳能和弥漫性X射线散射的研究，以确定结构的局部变化如何导致宏观特性。该仪器还用于研究单分散小纳米分子的合成以及用于二氧化碳还原和交叉偶联的催化剂的设计。衍射仪对生物大分子的研究有益于了解基因表达和抗生素耐药性。该奖项反映了NSF的法定任务，并且使用基金会的智力优点和更广泛的影响评估标准，被认为值得通过评估来获得支持。